Molecular structure of AMI-1, free acid, CAS Number: 134-47-4
AMI-1, free acid (CAS 134-47-4)
Alternate Names:
Scarlet acid; 7,7'-Carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid); 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)
Application:
AMI-1, free acid is a chemical shown to inhibit arginine, in vitro, with no inhibitory effect on lysine
CAS Number:
134-47-4
Purity:
≥98%
Molecular Weight:
504.49
Molecular Formula:
C21H16N2O9S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Experimentally shown to inhibit arginine, in vitro, with no inhibitory effect on lysine. No effect has been shown against S-adenosyl methionine (AdoMet), contrary to most methyltransferase inhibitors that show active competition for the AdoMet binding site. Studies have demonstrated AMI-1 to prevent cellular arginine methylation, modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, and is a HIV-1 reverse transcriptase inhibitor.
AMI-1, free acid (CAS 134-47-4) References
- Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach. | Feng, Y., et al. 2009. Biochem Biophys Res Commun. 379: 567-72. PMID: 19121292
- Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). | Castellano, S., et al. 2010. ChemMedChem. 5: 398-414. PMID: 20091730
- Endothelial transcriptome in response to pharmacological methyltransferase inhibition. | Okabe, J., et al. 2014. ChemMedChem. 9: 1755-62. PMID: 24850797
- Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5. | Zhang, B., et al. 2017. Toxicol Appl Pharmacol. 336: 1-7. PMID: 28987382
- Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling. | Zhu, Y., et al. 2020. Am J Physiol Renal Physiol. 318: F375-F387. PMID: 31813251
- PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells. | Bajbouj, K., et al. 2021. Int J Mol Sci. 22: PMID: 34200178
- Protein Arginine Methyltransferase (PRMT) Inhibitors-AMI-1 and SAH Are Effective in Attenuating Rhabdomyosarcoma Growth and Proliferation in Cell Cultures. | Janisiak, J., et al. 2021. Int J Mol Sci. 22: PMID: 34360791
- Downregulation of PRMT5 by AMI-1 enhances therapeutic efficacy of compound kushen injection in lung carcinoma in vitro and in vivo. | Yang, R., et al. 2023. Mol Cell Biochem. 478: 1031-1044. PMID: 36214894
- PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway. | Wang, F., et al. 2023. Genes Dis. 10: 2622-2638. PMID: 37554218
- In silico screening combined with bioactivity evaluation to identify AMI-1 as a novel anticancer compound by targeting AXL. | Wang, L., et al. 2023. J Biomol Struct Dyn. 1-13. PMID: 37691424
Inhibitor of:
HIV-1 RT, and PRMT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMI-1, free acid, 1 g | sc-300192 | 1 g | $96.00 |