Tenofovir Disoproxil Fumarate is an acyclic phosphonate nucleotide analog of tenofovir (sc-204335), a selective antiretroviral agent which functions as a HIV-1 RT (HIV reverse transcriptase) inhibitor.
Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),
Soluble in DMSO (128 mg/ml at 25° C), methanol, water (<1 mg/ml at 25° C), and ethanol (44 mg/ml at 25° C).
Store at 4° C
n20D ~1.58 (Predicted)
Human immunodeficiency virus 1: EC5050 = 2.9 nM; Human immunodeficiency virus 1: IC50 = 14 nM; HepG2: IC50 = 2.31 µM (human); Hepatitis B virus: IC50 = 5.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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