Tenofovir Disoproxil Fumarate CAS: 202138-50-9
MF: C19H30N5O10P•C4H4O4
MW: 635.51
An acyclic phosphonate nucleotide analog and selective HIV-1 RT inhibitor.

Tenofovir Disoproxil Fumarate (CAS 202138-50-9)

Tenofovir Disoproxil Fumarate | CAS 202138-50-9 is rated 5.0 out of 5 by 1.
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Alternate Names: Viread
Application: Tenofovir Disoproxil Fumarate is an acyclic phosphonate nucleotide analog and selective HIV-1 RT inhibitor
CAS Number: 202138-50-9
Purity: ≥98%
Molecular Weight: 635.51
Molecular Formula: C19H30N5O10P•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tenofovir Disoproxil Fumarate is an acyclic phosphonate nucleotide analog of tenofovir (sc-204335), a selective antiretroviral agent which functions as a HIV-1 RT (HIV reverse transcriptase) inhibitor.


References

Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Physical State :
Solid
Solubility :
Soluble in DMSO (128 mg/ml at 25° C), methanol, water (<1 mg/ml at 25° C), and ethanol (44 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
113-115° C
Refractive Index :
n20D ~1.58 (Predicted)
IC50 :
Human immunodeficiency virus 1: EC5050 = 2.9 nM; Human immunodeficiency virus 1: IC50 = 14 nM; HepG2: IC50 = 2.31 µM (human); Hepatitis B virus: IC50 = 5.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6398764
MDL Number :
MFCD08141829
SMILES :
C[[email protected]](CN1C=NC2=C1N=CN=C2N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.C(=C/C(=O)O)\\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Tenofovir Disoproxil Fumarate (CAS 202138-50-9)  Product Citations

See how others have used Tenofovir Disoproxil Fumarate (CAS 202138-50-9). Click on the entry to view the PubMed entry .

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PMID: # 22499243  Gokulgandhi, MR. et al. 2012. Journal of pharmaceutical sciences. 101: 3249-63.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a white powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2018-08-04
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Rated 5 out of 5 by from Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate, was reported in many articles as an anitretroviral. -SCBT Publication Review
Date published: 2015-03-17
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