Tenofovir (CAS 147127-20-6)
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Tenofovir is a compound extensively researched in the context of its action pertaining to retroviruses. In the field of virology, it serves as a cornerstone for studying viral replication mechanisms. Due to its mode of action as a nucleotide analog reverse transcriptase inhibitor, tenofovir is instrumental in understanding the intricacies of viral DNA synthesis. Researchers also employ it to investigate the development of viral resistance, exploring the genetic mutations that contribute to this phenomenon. In cellular studies, tenofovir is used to discern the effects of reverse transcription inhibition on viral lifecycle and host cell interactions. Moreover, tenofovir′s impact on cellular enzymes and nucleotide pools is a subject of research, contributing to the broader understanding of cellular metabolism and the consequences of nucleotide analog incorporation.
Tenofovir (CAS 147127-20-6) References
- Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors. | Cihlar, T., et al. 2002. Antiviral Res. 54: 37-45. PMID: 11888656
- Tenofovir and bone health. | Grant, PM. and Cotter, AG. 2016. Curr Opin HIV AIDS. 11: 326-32. PMID: 26859637
- Is Tenofovir Alafenamide Safer than Tenofovir Disoproxil Fumarate for the Kidneys? | Aloy, B., et al. 2016. AIDS Rev. 18: 184-192. PMID: 27438578
- Tenofovir for Prevention of HIV Infection. | Kaufman, B. and Zehtabchi, S. 2017. Am Fam Physician. 96: Online. PMID: 28671379
- Tenofovir Urine Assay to Monitor Adherence to HIV Pre-exposure Prophylaxis. | Moorthy, GS., et al. 2020. Curr Clin Pharmacol. 15: 102-104. PMID: 31713497
- Tenofovir alafenamide vs. tenofovir disoproxil fumarate: an updated meta-analysis of 14 894 patients across 14 trials. | Pilkington, V., et al. 2020. AIDS. 34: 2259-2268. PMID: 33048869
- Tenofovir alafenamide revisited. | Di Perri, G. 2020. Infez Med. 28: 525-533. PMID: 33257626
- Tenofovir alafenamide nephrotoxicity: a case report and literature review. | Ueaphongsukkit, T., et al. 2021. AIDS Res Ther. 18: 53. PMID: 34419091
- Efficacy of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide in treatment-naive hepatitis B patients. | Chon, HY., et al. 2021. Hepatol Int. 15: 1328-1336. PMID: 34799838
- The use of tenofovir in patients with COVID-19. | Kow, CS., et al. 2022. HIV Med. 23: 807-808. PMID: 35023263
- Tenofovir alafenamide fumarate. | Lee, WA. and Cheng, AK. 2022. Antivir Ther. 27: 13596535211067600. PMID: 35499175
- Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. | Tsai, CC., et al. 1995. Science. 270: 1197-9. PMID: 7502044
- 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. | Van Rompay, KK., et al. 1996. Antimicrob Agents Chemother. 40: 2586-91. PMID: 8913470
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tenofovir, 10 mg | sc-204335 | 10 mg | $157.00 | |||
Tenofovir, 50 mg | sc-204335A | 50 mg | $646.00 |