Lamivudine (CAS 134678-17-4)
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Lamivudine, a synthetic nucleoside analogue, plays a role in the study of viral replication mechanisms, particularly within the context of HIV and Hepatitis B viruses. As a potent inhibitor of reverse transcriptase, an enzyme pivotal for the transcription of viral RNA into DNA, Lamivudine integrates into the viral DNA chain during replication. This incorporation results in chain termination, effectively halting the virus′s ability to replicate. Its mechanism underscores the dynamic interplay between viral enzymes and nucleoside analogues, offering a window into understanding viral resistance and the evolution of antiviral strategies. In research, Lamivudine serves as a tool to dissect the complexities of viral life cycles, providing insights into the molecular underpinnings of viral persistence and the development of resistance, thereby contributing to the broader field of antiviral drug discovery and the quest for more effective treatments for viral infections.
Lamivudine (CAS 134678-17-4) References
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- Lamivudine prophylaxis in HBV carriers with haemato-oncological malignancies who receive chemotherapy. | Idilman, R. 2005. J Antimicrob Chemother. 55: 828-31. PMID: 15849263
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- Antenatal lamivudine to reduce perinatal hepatitis B transmission: a cost-effectiveness analysis. | Nayeri, UA., et al. 2012. Am J Obstet Gynecol. 207: 231.e1-7. PMID: 22939730
- Lamivudine-Induced Skin Rash Remains an Underdiagnosed Entity in HIV: A Case Series from a Single Center. | Sachdeva, RK., et al. 2016. J Int Assoc Provid AIDS Care. 15: 153-8. PMID: 26310925
- Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients. | Bouazza, N., et al. 2017. J Antimicrob Chemother. 72: 490-495. PMID: 27798221
- Semi-continuous multi-step synthesis of lamivudine. | Mandala, D., et al. 2017. Org Biomol Chem. 15: 3444-3454. PMID: 28362445
- Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder. | Mdanda, S., et al. 2019. Assay Drug Dev Technol. 17: 322-329. PMID: 31634020
- Lamivudine improves cognitive decline in SAMP8 mice: Integrating in vivo pharmacological evaluation and network pharmacology. | Li, M., et al. 2021. J Cell Mol Med. 25: 8490-8503. PMID: 34374199
- Environmental Risk Characterization of an Antiretroviral (ARV) Lamivudine in Ecosystems. | Omotola, EO., et al. 2021. Int J Environ Res Public Health. 18: PMID: 34444108
- Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndrome. | Martinez de Lagran, M., et al. 2022. J Cell Mol Med. 26: 4210-4215. PMID: 35762509
- Lamivudine remedies alcoholism by activating acetaldehyde dehydrogenase. | Han, L., et al. 2022. Biochem Pharmacol. 203: 115199. PMID: 35917871
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamivudine, 10 mg | sc-221830 | 10 mg | $102.00 | |||
Lamivudine, 50 mg | sc-221830A | 50 mg | $214.00 |