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2′,3′-Dideoxyinosine, also known as ddI, has been a subject of extensive scientific research, particularly in the fields of virology and nucleic acid biochemistry. This compound has been primarily studied for its unique mechanism of action as a nucleoside analog reverse transcriptase inhibitor (NRTI). Specifically, ddI interferes with the replication of retroviruses, such as HIV, by inhibiting the reverse transcriptase enzyme essential for viral DNA synthesis. This inhibition occurs through competitive incorporation of ddI into the growing viral DNA chain, which leads to premature termination of DNA synthesis, thereby preventing viral replication. Moreover, ddI has been utilized as a molecular tool in elucidating the mechanisms of nucleic acid synthesis and DNA polymerase function. Studies have employed ddI to investigate the kinetics and fidelity of DNA polymerases, as well as to explore the structural basis of nucleoside analog incorporation into DNA. Additionally, research has utilized 2′,3′-dideoxyinosine (ddI) in studies aimed at understanding the mechanisms of viral resistance. Investigations have focused on identifying mutations in the reverse transcriptase enzyme that confer resistance to ddI, providing insights into the molecular basis of antiretroviral resistance.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2',3'-Dideoxyinosine, 1 mg | sc-205098 | 1 mg | $40.00 | |||
2',3'-Dideoxyinosine, 5 mg | sc-205098A | 5 mg | $146.00 |