Molecular structure of Luzopeptin A, CAS Number: 75580-37-9
Luzopeptin A (CAS 75580-37-9)
See product citations (8)
Application:
Luzopeptin A is an inhibitor of HIV-1 and HIV-2 reverse transcriptase
CAS Number:
75580-37-9
Purity:
>99%
Molecular Weight:
1427.4
Molecular Formula:
C64H78N14O24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Luopeptin A is a strong antitumor and antibioitic agent from the echinomycin class. Inhibitor of HIV-1and HIV-2 reverse transcriptase. Luzopeptin A forms a very stable complex with DNA via bi-intercalation. Part of echinomycin class of cyclic depsipeptides containing a quinoline nucleus as the chromophore.
Luzopeptin A (CAS 75580-37-9) References
- DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin. | Bailly, C., et al. 2000. Nucleosides Nucleotides Nucleic Acids. 19: 1337-53. PMID: 11097063
- Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. | Leroy, JL., et al. 1992. Biochemistry. 31: 1407-15. PMID: 1310611
- Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. | Watanabe, K., et al. 2006. Nat Chem Biol. 2: 423-8. PMID: 16799553
- The strong binding of luzopeptin to DNA. | Fox, KR. and Woolley, C. 1990. Biochem Pharmacol. 39: 941-8. PMID: 2310419
- Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS-virus. | Inouye, Y., et al. 1987. J Antibiot (Tokyo). 40: 100-4. PMID: 2435692
- Effects of structural modifications of anti-tumour antibiotics luzopeptins on cell growth and macromolecule biosynthesis. | Huang, CH. and Crooke, ST. 1986. Anticancer Drug Des. 1: 87-94. PMID: 2453197
- In vivo characterization of P388 leukemia resistant to mitomycin C. | Rose, WC., et al. 1987. In Vivo. 1: 47-52. PMID: 2979764
- Effects of structural modifications of antitumor antibiotics (luzopeptins) on the interactions with deoxyribonucleic acid. | Huang, CH. and Crooke, ST. 1985. Cancer Res. 45: 3768-73. PMID: 4016750
- Intermolecular cross-linking of DNA through bifunctional intercalation of an antitumor antibiotic, luzopeptin A (BBM-928A). | Huang, CH., et al. 1983. Cancer Res. 43: 2718-24. PMID: 6303566
- BBM-928, a new antitumor antibiotic complex. III. Structure determination of BBM-928 A, B and C. | Konishi, M., et al. 1981. J Antibiot (Tokyo). 34: 148-59. PMID: 7298509
- BBM-928, a new antitumor antibiotic complex. I. Production, isolation, characterization and antitumor activity. | Ohkuma, H., et al. 1980. J Antibiot (Tokyo). 33: 1087-97. PMID: 7451357
- BBM-928, a new antitumor antibiotic complex. II. Taxonomic studies on the producing organism. | Tomita, K., et al. 1980. J Antibiot (Tokyo). 33: 1098-102. PMID: 7451358
- Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity. | Lingham, RB., et al. 1996. J Antibiot (Tokyo). 49: 253-9. PMID: 8626240
Inhibitor of:
HIV-1 RT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Luzopeptin A, 1 mg | sc-202214 | 1 mg | $288.00 |