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β-Rubromycin is a quinone antibiotic agent. β-Rubromycin is found to inhibit reverse HIV-1 RT (transcrisptase from HIV-1) to a greater degree than it inhibits cellular DNA polymerase α. This compound also inhibits TERT (human telomerase), and is cytostatically active against different tumor cell lines.
Goldman ME, Salituro GS, Bowen JA et al. Mol Pharmacol. 38:20-25 (1990).
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