Emtricitabine-13C,15N2 (CAS 1217820-69-3)
QUICK LINKS
Emtricitabine-13C,15N2 is a labeled Emtricitabine (sc- 207617) which inhibits HIV-1 reverse transcriptase (HIV-1 RT) and can cause termination of DNA chain elongation in the virus via incorporation into the viral genome. Emtricitabine-13C,15N2 has found extensive use in diverse research endeavors, including the exploration of the mechanisms of action of HIV-1 reverse transcriptase (RT) inhibitors, the formulation of novel drug compositions, and the investigation of drug-target interactions. This compound is particularly valuable for labeling HIV-1 RT inhibitors, enabling the precise determination of their binding affinity to the enzyme. Moreover, it plays a role in studying the in vitro metabolism of FTC (emtricitabine) and its metabolites, contributing to a deeper understanding of their pharmacokinetics and potential therapeutic implications.
Emtricitabine-13C,15N2 (CAS 1217820-69-3) References
- Simultaneous determination of intracellular concentrations of tenofovir, emtricitabine, and dolutegravir in human brain microvascular endothelial cells using liquid chromatography-tandem mass spectrometry (LC-MS/MS). | Patel, SH., et al. 2019. Anal Chim Acta. 1056: 79-87. PMID: 30797464
- Study on Pharmacokinetic Interactions Between HS-10234 and Emtricitabine in Healthy Subjects: An Open-Label, Two-Sequence, Self-Controlled Phase I Trial. | Luo, Y., et al. 2022. Infect Dis Ther. 11: 175-186. PMID: 34727366
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Emtricitabine-13C,15N2, 500 µg | sc-218303 | 500 µg | $663.00 |