H2-Dd Inhibitors
H2-Dd inhibitors are a specialized class of chemical compounds designed to target the H2-Dd protein, which belongs to the major histocompatibility complex (MHC) class I family. MHC class I molecules play a pivotal role in the immune system by presenting peptide fragments found in intracellular proteins to cytotoxic T lymphocytes (CTLs). This presentation is crucial for CTLs to recognize and eliminate infected or abnormal cells. H2-Dd is specifically found in mice and serves as an MHC class I molecule that presents antigenic peptides to CD8+ T cells, contributing to immune surveillance and immune responses against pathogens and abnormal cells.
Inhibitors of H2-Dd are designed to interact with this protein and disrupt its ability to present antigenic peptides to CTLs. These inhibitors may operate through various mechanisms, such as binding to specific regions of H2-Dd or altering its conformation. Research on H2-Dd inhibitors is primarily focused on elucidating the molecular mechanisms by which H2-Dd participates in antigen presentation and immune responses, contributing to our understanding of the complex interactions between the immune system and target cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that may modulate NF-κB activity, potentially downregulating MHC class I expression including H2-Dd. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A natural compound with multiple targets that may alter NF-κB signaling, which can affect H2-Dd expression. | ||||||
Chloroquine Sulphate | 132-73-0 | sc-337629 | 25 mg | $224.00 | 2 | |
that can inhibit lysosomal activity and may influence antigen processing and MHC class I expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could impair MHC class I antigen presentation and reduce H2-Dd surface expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A peptide aldehyde that inhibits the proteasome, potentially affecting H2-Dd turnover and expression. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
A tyrosine kinase inhibitor that might alter signaling pathways involved in the regulation of MHC class I expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could impact the epigenetic regulation of genes, including those for MHC class I. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Another DNA methyltransferase inhibitor that may affect the epigenetic state and expression of H2-Dd. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
An aldehyde dehydrogenase inhibitor that can modulate NF-κB activity and potentially influence H2-Dd expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor that affects chromatin structure and could indirectly decrease H2-Dd gene transcription. | ||||||