Date published: 2026-1-7

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Imatinib (CAS 152459-95-5)

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Alternate Names:
4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Application:
Imatinib is an inhibitor of multiple tyrosine kinases
CAS Number:
152459-95-5
Purity:
≥98%
Molecular Weight:
493.60
Molecular Formula:
C29H31N7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Imatinib is a compound that garners considerable attention in biochemical research due to its ability to selectively inhibit certain tyrosine kinases. It is widely studied for its mechanism of action, which involves the stabilization of the inactive form of the kinase, thereby impeding downstream signaling pathways that are in various cellular processes. Research on imatinib has primarily focused on its interaction with the BCR-ABL kinase, an abnormal tyrosine kinase that is implicated in specific cellular proliferation disorders. Investigations into the binding affinity and specificity of imatinib to its targets are key to understanding how it can modulate aberrant kinase activity. Moreover, the compound is used as a tool in studies exploring the cellular and molecular consequences of kinase inhibition, including alterations in gene expression, cell cycle progression, and apoptosis. Imatinib also serves as a lead compound in the design and synthesis of new molecules with similar or improved efficacy and selectivity profiles.


Imatinib (CAS 152459-95-5) References

  1. Imatinib prevents lung cancer metastasis by inhibiting M2-like polarization of macrophages.  |  Yao, Z., et al. 2018. Pharmacol Res. 133: 121-131. PMID: 29730267
  2. Factors Influencing Imatinib-Induced Hepatotoxicity.  |  Han, JM., et al. 2020. Cancer Res Treat. 52: 181-188. PMID: 31291714
  3. Synthesis of imatinib, a tyrosine kinase inhibitor, labeled with carbon-14.  |  Kang, J., et al. 2020. J Labelled Comp Radiopharm. 63: 174-182. PMID: 31975483
  4. Imatinib exhibit synergistic pleiotropy in the prevention of colorectal cancer by suppressing proinflammatory, cell survival and angiogenic signaling.  |  Dhiman, DK., et al. 2020. Cell Signal. 76: 109803. PMID: 33022360
  5. Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice.  |  Pichavaram, P., et al. 2021. Eur J Pharmacol. 890: 173666. PMID: 33131722
  6. Long induction of tolerance to imatinib.  |  Bojanini, L., et al. 2020. BMJ Case Rep. 13: PMID: 33318243
  7. Starting Imatinib at 400 mg Daily in Patients with Gastrointestinal Stromal Tumors Harboring KIT Exon 9 Mutations: A Retrospective, Multicenter Study.  |  Callejo, A., et al. 2021. Target Oncol. 16: 485-492. PMID: 34089444
  8. Imatinib reduces the fertility of male mice by penetrating the blood-testis barrier and inducing spermatogonia apoptosis.  |  Chang, X., et al. 2021. Reprod Biol. 21: 100527. PMID: 34147007
  9. DRESS syndrome induced by imatinib.  |  Kaur, S., et al. 2021. J Postgrad Med. 67: 158-163. PMID: 34427280
  10. Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model.  |  Mukai, T., et al. 2023. Oral Dis. 29: 1089-1101. PMID: 34743383
  11. Imatinib can act as an Allosteric Activator of Abl Kinase.  |  Xie, T., et al. 2022. J Mol Biol. 434: 167349. PMID: 34774565
  12. Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism.  |  Strobelt, R., et al. 2022. Sci Rep. 12: 5758. PMID: 35388061
  13. Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors.  |  Chiba, K., et al. 2022. J Pharmacol Sci. 150: 154-162. PMID: 36184120
  14. Imatinib suppresses activation of hepatic stellate cells by targeting STAT3/IL-6 pathway through miR-124.  |  Alavifard, H., et al. 2023. Cell Biol Int. 47: 969-980. PMID: 36655489
  15. Imatinib-induced lichen planus and lichenoid drug eruption: A report of three cases.  |  Almheirat, Y., et al. 2023. J Cutan Pathol. 50: 415-419. PMID: 36789996

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Imatinib, 10 mg

sc-267106
10 mg
$26.00

Imatinib, 100 mg

sc-267106A
100 mg
$119.00

Imatinib, 1 g

sc-267106B
1 g
$213.00