GPR82 Activators
GPR82 is a G protein-coupled receptor (GPCR) whose activity can be affected by various agents through different mechanisms. Certain compounds are known to directly activate adenylate cyclase, increasing cyclic AMP (cAMP) concentrations within the cell. This rise in cAMP activates protein kinase A (PKA), which may phosphorylate and activate GPR82, thereby modulating its signaling cascade. Other agents function as non-selective beta-adrenergic agonists, further elevating intracellular cAMP levels through Gs protein activation and enhancing PKA-mediated phosphorylation of GPR82. Muscarinic acetylcholine receptor agonists or nicotinic receptor agonists can alter G-protein signaling in a manner that changes G-protein coupling preferences, potentially affecting GPR82's activity. Similarly, histamine, acting through its own GPCRs, can influence the cellular signaling environment and alter the activity of other GPCRs, including GPR82, through modifications in G-protein signaling dynamics.
Additional chemical agents can indirectly influence the activation of GPR82 through diverse pathways. For example, the activation of TRPV1 receptors by certain ligands leads to a calcium influx, which has extensive effects on GPCR activity, including the possible upregulation of GPR82. Antagonists of adenosine receptors can increase catecholamine release, enhancing GPCR signaling pathways and potentially activating GPR82. Moreover, alterations in prostaglandin levels due to the influence of certain anti-inflammatory drugs might impact GPR82 activity. Nitric oxide donors engaging cGMP pathways caninfluence the activation of protein kinase G (PKG), which has the potential to phosphorylate and thus modulate GPCR functions, including those of GPR82. Additionally, adrenergic receptor agonists may induce crosstalk between adrenergic signaling and other GPCR pathways, possibly enhancing GPR82 activity. Cholinergic agonists that act on muscarinic receptors can affect the GPCR signaling milieu, which could indirectly influence GPR82's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate GPR82, potentially leading to its activation and an increase in its downstream signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A non-selective beta-adrenergic agonist that elevates intracellular cAMP levels via Gs protein activation. The resultant activation of PKA may enhance the phosphorylation and activation of GPR82. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
A muscarinic acetylcholine receptor agonist that can modulate G-protein signaling. Activation of the muscarinic pathway might lead to a change in G-protein coupling preference or downstream effects that could result in the activation of GPR82. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Acting through its G-protein coupled histamine receptors, histamine can influence the signaling landscape of the cell, potentially affecting the activity of other GPCRs such as GPR82 through alterations in G-protein signaling dynamics. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Activates the TRPV1 receptor, leading to calcium influx. The change in intracellular calcium levels can have widespread effects on GPCR activity, including potentially increasing the functional activity of GPR82. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Known to antagonize adenosine receptors, which are GPCRs, resulting in increased catecholamine release. This can enhance GPCR signaling pathways, potentially activating GPR82 indirectly. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Can influence GPCR signaling by altering prostaglandin levels, which may impact the activity of GPR82. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Donors release nitric oxide which can engage in cGMP pathways, influencing the activity of PKG. PKG can phosphorylate various proteins, potentially affecting GPCR function including GPR82. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Acts as an agonist to adrenergic receptors which are GPCRs. This can lead to cross-talk between adrenergic signaling and other GPCR pathways, potentially enhancing the activity of GPR82. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $120.00 $275.00 $380.00 $670.00 $1400.00 $3000.00 | 12 | |
A cholinergic agonist that acts on muscarinic acetylcholine receptors and can modulate GPCR signaling. This may indirectly influence the activity of GPR82 through changes in the G-protein signaling landscape. | ||||||