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Sodium nitroprusside (SNP), Dihydrate, is a nitric oxide donor/releaser and potent vasodilator, which has been reported to reduce lipid peroxidation-induced membrane damage, and is believed to exert its vasodilating activity through the vascular activation of nitric oxide. SNP is useful for quantitative ammonium analysis, as well as chromatographic detection of cystine-containing peptides. It has also been reported to be beneficial in maintaining post-thaw sperm viability and motion for up to 6 hours, which has been attributed to the reduction of lipid peroxidative damage to the sperm membrane substances.
1. Kowaluk, E A., et al., 1992. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. The Journal of pharmacology and experimental therapeutics. 262(3): 916-22. PMID: 1527732
2. Ignarro, L J., et al., 1981. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. The Journal of pharmacology and experimental therapeutics. 218(3): 739-49. PMID: 6115052
3. Hellstrom, W J., et al., 1994. Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation. Fertility and sterility. 61(6): 1117-22. PMID: 8194627
See how others have used Sodium nitroprusside dihydrate. Click on the entry to view the PubMed entry .
PMID: # 27158388 Xu, Z. et al. 2016. Am J Transl Res. 8: 1027-36.
PMID: # 19479373 Svensson, G. et al. 2009. Glycoconj. J. 26: 1247-1257.
PMID: # 19202197 Kawachi, M. et al. 2008. Gen. Physiol. Biophys. 27: 243-252.
PMID: # 18502941 Dallabrida, SM. et al. 2008. FASEB J. 22: 3010-3023.
PMID: # 17997517 Wu, J. et al. 2007. J. Proteome Res. 6: 4728-4736.
PMID: # 16199577 Hahn, MY. et al. 2005. J. Bacteriol. 187: 7062-7071.
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