Histamine, free base CAS: 51-45-6
MF: C5H9N3
MW: 111.15
A compound that activates NOS which results in the release of NO.

Histamine, free base (CAS 51-45-6)

Histamine, free base | CAS 51-45-6 is rated 4.0 out of 5 by 1.
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Alternate Names: 1H-Imidazole-4-ethanamine; Ergotidine; 2-(4-Imidazolyl)ethylamine
Application: Histamine, free base is a compound that activates NOS which results in the release of NO
CAS Number: 51-45-6
Purity: ≥97%
Molecular Weight: 111.15
Molecular Formula: C5H9N3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Histamine, free base is a potent vasodilator found in normal tissues and blood. This compound is formed by the decarboxylation of L-histidine and activates NOS (nitric oxide synthase), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.


References

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178. Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477. Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952. Yan, Q.Z., et al. 1994. Agents Actions 41, C111. Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109. Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

Physical State :
Solid
Solubility :
Soluble in water, alcohol, and hot chloroform.
Storage :
Store at 4° C
Melting Point :
83-84° C
Boiling Point :
167° C at 0.8 mmHg
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Histamine H1 receptor: IC50 = ~1 µM (human)
Ki Data :
Histamine H3 receptor: Ki= 5.2 nM (human); Histamine H4 Receptor: Ki= 7.94 nM (human)
pK Values :
pKb: 9.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MS1050000
PubChem CID :
774
Merck Index :
14: 4719
MDL Number :
MFCD00005210
EC Number :
200-100-6
Beilstein Registry :
2012
SMILES :
C1=C(NC=N1)CCN

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Certificate of Analysis

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Histamine, free base (CAS 51-45-6)  Product Citations

See how others have used Histamine, free base (CAS 51-45-6). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 11880261  Fischer, H. et al. 2002. Am. J. Physiol., Cell Physiol. 282: C736-C743.

PMID: # 8475118  Sudweeks, JD. et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 3700-3704.

Linthicum, D. et al. 1982. J. Exp. Med. 156: 31-40.

PMID: # 4549916  Sofia, RD. et al. 1974. Life Sci. 15: 251-260.

Citations 1 to 4 of 4 total

Hi, we are looking for high purity of histamine. Could you please share with us your purification method as reference as well as the characterization method to determine the purity? Thanks!

Asked by: sunny66
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2017-05-30
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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