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Histamine, free base (CAS 51-45-6)

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Alternate Names:
1H-Imidazole-4-ethanamine; Ergotidine; 2-(4-Imidazolyl)ethylamine
Application:
Histamine, free base is a compound that activates NOS which results in the release of NO
CAS Number:
51-45-6
Purity:
≥96%
Molecular Weight:
111.15
Molecular Formula:
C5H9N3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Histamine is a potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.


Histamine, free base (CAS 51-45-6) References

  1. Structural and vibrational study of the tautomerism of histamine free-base in solution.  |  Ramírez, FJ., et al. 2003. J Am Chem Soc. 125: 2328-40. PMID: 12590563
  2. Selective determination of histamine by flow injection analysis.  |  Hungerford, JM., et al. 1990. Anal Chem. 62: 1971-6. PMID: 2240576
  3. Detection of histamine in human placental perfusate and the effect of histamine releasers.  |  Kohler, FW., et al. 1988. Res Commun Chem Pathol Pharmacol. 61: 185-200. PMID: 2460906
  4. Hyperosmolarity but not histamine evokes secretion of nasal fluid in the rat.  |  Petersson, G., et al. 1989. Eur J Pharmacol. 161: 37-43. PMID: 2566487
  5. Histamine selective microelectrode based on a synthetic organic liquid ion exchanger.  |  Bi, Y. 1989. Biosensors. 4: 373-80. PMID: 2818654
  6. pH-induced conformational changes in histamine in the solid state.  |  Kodchakorn, K., et al. 2019. RSC Adv. 9: 19375-19389. PMID: 35519396
  7. Experimental allergic orchitis in mice. II. Association of disease susceptibility with the locus controlling Bordetella pertussis-induced sensitivity to histamine.  |  Teuscher, C. 1985. Immunogenetics. 22: 417-25. PMID: 4065933
  8. The complexing of histamine with p-benzoquinone.  |  Moxon, GH. and Slifkin, MA. 1972. Biochim Biophys Acta. 286: 98-102. PMID: 4659269
  9. Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines.  |  Rothwell, TL., et al. 1974. Int Arch Allergy Appl Immunol. 46: 1-13. PMID: 4814291
  10. Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.  |  Linthicum, DS. and Frelinger, JA. 1982. J Exp Med. 156: 31-40. PMID: 6806429
  11. Quality control of phenylbutazone II: Analysis of phenylbutazone and its decomposition products in drugs by high-pressure liquid chromatography.  |  Fabre, H., et al. 1982. J Pharm Sci. 71: 120-2. PMID: 7057365
  12. Relaxant responses of the isolated guinea-pig left pulmonary artery produced by acidic histamine solutions.  |  Hand, JM. and Buckner, CK. 1981. Eur J Pharmacol. 70: 225-30. PMID: 7262186
  13. Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae--studies in vivo and in vitro.  |  Kemp, DH. and Bourne, A. 1980. Parasitology. 80: 487-96. PMID: 7393620
  14. Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors.  |  Fleckenstein, AE., et al. 1993. Naunyn Schmiedebergs Arch Pharmacol. 347: 50-4. PMID: 8446183
  15. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.  |  Sudweeks, JD., et al. 1993. Proc Natl Acad Sci U S A. 90: 3700-4. PMID: 8475118

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Histamine, free base, 1 g

sc-204000
1 g
$92.00

Histamine, free base, 5 g

sc-204000A
5 g
$277.00

Histamine, free base, 25 g

sc-204000B
25 g
$969.00

Hi, we are looking for high purity of histamine. Could you please share with us your purification method as reference as well as the characterization method to determine the purity? Thanks!

Asked by: sunny66
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2017-05-30
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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Histamine, free base is rated 4.0 out of 5 by 1.
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