Histamine, free base is a potent vasodilator found in normal tissues and blood. This compound is formed by the decarboxylation of L-histidine and activates NOS (nitric oxide synthase), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178. Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477. Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952. Yan, Q.Z., et al. 1994. Agents Actions 41, C111. Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109. Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
we are looking for high purity of histamine. Could you please share with us your purification method as reference as well as the characterization method to determine the purity?
Asked by: sunny66
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
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