GPR82 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that targets a wide range of kinases involved in various signaling pathways. Inhibition of these kinases disrupts downstream signaling which could inhibit GPR82 activation or reduce its expression due to altered cellular signaling dynamics. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
C-Raf kinase inhibitor that impedes the MAPK/ERK pathway. As kinase cascades are essential for various receptor functions, GPR82 activity or signaling could be indirectly attenuated due to impaired phosphorylation events within the cascade. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that disrupts the PI3K/Akt pathway, which is integral to many GPCR-mediated functions. This could lead to a decrease in GPR82-mediated signaling through reduced downstream Akt activation, inhibiting its functional activity. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
An inhibitor of G(i/o) protein coupling, which can prevent GPR82 from exerting its effects via this G protein subfamily, thereby inhibiting its signaling capabilities. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that could hinder Rho-associated kinase pathways. As these are linked to GPCR function, GPR82 signaling could be indirectly inhibited due to downstream effects on cytoskeletal reorganization and cell motility. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A broad-spectrum protein kinase C inhibitor which could attenuate signaling pathways that are activated downstream of GPR82, indirectly leading to its inhibition by altering the receptor's ability to initiate intracellular responses. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Another protein kinase C inhibitor that could indirectly inhibit GPR82 by disrupting its associated signaling pathways, preventing normal receptor function and downstream signaling events. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that disrupts the MAPK/ERK pathway downstream of various GPCRs, leading to decreased GPR82 signaling through reduced ERK1/2 phosphorylation and activity. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A | 50 mg 500 mg | $68.00 $357.00 | 11 | |
Known to bind to various GPCRs and could antagonize GPR82, leading to decreased receptor activation and signaling capacity. | ||||||
Gabazine | 105538-73-6 | sc-211552 | 10 mg | $714.00 | 3 | |
A GABA receptor antagonist that, while its primary action is on GABA receptors, may also exhibit off-target effects on other GPCRs, inhibiting GPR82 activity through altered neurotransmission and receptor crosstalk. | ||||||