Molecular structure of Gabazine, CAS Number: 105538-73-6
Gabazine (CAS 105538-73-6)
See product citations (3)
Alternate Names:
2-(3-Carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium SR-95531 SR95531 SR 95531
Application:
Gabazine is a specific GABA receptor antagonist
CAS Number:
105538-73-6
Molecular Weight:
287.31
Molecular Formula:
C15H17N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gabazine is a specific GABA receptor antagonist which does not affect GABA-transaminase or glutamate-decarboxylase activitites. Gabazine, also known as SR-95531, is a selective antagonist of the GABA-A receptor. It is a chemical compound that specifically blocks the activity of GABA receptors in the brain. By binding to GABA-A receptors, Gabazine prevents the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA), leading to an increase in neuronal excitability.
Gabazine (CAS 105538-73-6) References
- Differential paired-pulse effects of gabazine and bicuculline in rat hippocampal CA3 area. | Margineanu, DG. and Wülfert, E. 2000. Brain Res Bull. 51: 69-74. PMID: 10654583
- Multi-neuronal recordings reveal a differential effect of thapsigargin on bicuculline- or gabazine-induced epileptiform excitability in rat hippocampal neuronal networks. | Sokal, DM., et al. 2000. Neuropharmacology. 39: 2408-17. PMID: 10974325
- Pallidal administrations of gabazine and 5-AVA affect pressure-induced behavioral disorders in rats. | Darbin, O., et al. 2002. Pharmacol Biochem Behav. 71: 319-24. PMID: 11812539
- Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex. | Kurt, S., et al. 2006. Hear Res. 212: 224-35. PMID: 16442250
- Effects of the GABA(A) receptor antagonists bicuculline and gabazine on stimulus-induced sharp wave-ripple complexes in adult rat hippocampus in vitro. | Behrens, CJ., et al. 2007. Eur J Neurosci. 25: 2170-81. PMID: 17419756
- Differential effects of iontophoretic application of the GABAA-antagonists bicuculline and gabazine on tone-evoked local field potentials in primary auditory cortex: interaction with ketamine anesthesia. | Kurt, S., et al. 2008. Brain Res. 1220: 58-69. PMID: 18022607
- Sequential steps underlying neuronal plasticity induced by a transient exposure to gabazine. | Pegoraro, S., et al. 2010. J Cell Physiol. 222: 713-28. PMID: 20027606
- Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). | Gavande, N., et al. 2010. Org Biomol Chem. 8: 4131-6. PMID: 20657924
- The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus. | Savrasova, AV., et al. 2010. Fiziol Zh (1994). 56: 14-8. PMID: 20964139
- Synthesis and evaluation of highly potent GABA(A) receptor antagonists based on gabazine (SR-95531). | Iqbal, F., et al. 2011. Bioorg Med Chem Lett. 21: 4252-4. PMID: 21664131
- Effect of gabazine on sensory stimulation train evoked response in mouse cerebellar Purkinje cells. | Bing, YH., et al. 2015. Pharmazie. 70: 129-34. PMID: 25997254
- Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons. | Chesnoy-Marchais, D. 2016. Neuroscience. 330: 191-204. PMID: 27246441
- Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels. | Müller, S., et al. 2018. Neurobiol Dis. 112: 79-84. PMID: 29330041
- Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. | Ueno, S., et al. 1997. J Neurosci. 17: 625-34. PMID: 8987785
Inhibitor of:
Cerebellin 1, Gγ 12, Gab 1, GABA Receptor, GABAA θ, GABAA 3, GABAA R rho 1, GABAA Rα2, GABAA Rα4, GABAA Rα6, GABAA Rβ3, GABAA Rδ, GABAA Rε, GABAA Rγ2, GABAA Rγ3, GABAA Rγ4, GABAA Rθ, GABAA Rp, GABAC Rρ2, Gephyrin, GlyR α1 (GLRA1), neuroligin 3, neuropsin, PRRT2, SAPAP4, V1RB1, VGAT, Vmn1r152, Vmn2r57, WDR62, and ZNF175.Activator of:
neuroligin 3, and Otoferlin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gabazine, 10 mg | sc-211552 | 10 mg | $714.00 |