Molecular structure of Clozapine, CAS Number: 5786-21-0
Clozapine (CAS 5786-21-0)
See product citations (11)
Alternate Names:
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
Application:
Clozapine is a selective inhibitor for D4-dopamine and several serotonin receptors
CAS Number:
5786-21-0
Purity:
≥98%
Molecular Weight:
326.8
Molecular Formula:
C18H19ClN4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clozapine preferentially inhibits D4DR (D4-dopamine receptor) and SR-2 and acts as a weak D1 and D2 antagonist. Clozapine is also reported to inhibit SR-2A, SR-2C, SR-3, SR-6 and SR-7. Two major metabolites of Clozapine are reported to be N-Desmethyl Clozapine (labeled compound sc-219117) and Clozapine N-oxide (sc-201111). Additionally, reversed-phase HPLC has been reported as a method of identification of Clozapine and its two major metabolites. In studies investigating the induction of neutrophil apoptosis in rabbits by oxidation of Clozapine into reactive nitrenium ion, it was noted that Clozapine increased the rate of neutrophil release from bone marrow while also affecting the neutrophil half-life in the peripheral blood stream of rabbits. Clozapine is also available as a labeled analog (sc-217944). Clozapine is an inhibitor of D2DR.
Clozapine (CAS 5786-21-0) References
- Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. | Bergqvist, PB., et al. 1999. Psychopharmacology (Berl). 143: 89-96. PMID: 10227084
- Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. | Zhukovskaya, NL. and Neumaier, JF. 2000. Neurosci Lett. 288: 236-40. PMID: 10889351
- Simultaneous determination of clozapine, norclozapine and clozapine-N-oxide in human plasma by high-performance liquid chromatography with ultraviolet detection. | Liu, YY., et al. 2001. Biomed Chromatogr. 15: 280-6. PMID: 11438972
- Latent inhibition in 35-day-old rats is not an 'adult' latent inhibition: implications for neurodevelopmental models of schizophrenia. | Zuckerman, L., et al. 2003. Psychopharmacology (Berl). 169: 298-307. PMID: 12827344
- Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. | Zuckerman, L., et al. 2003. Neuropsychopharmacology. 28: 1778-89. PMID: 12865897
- Aripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex. | Zocchi, A., et al. 2005. Neurosci Lett. 387: 157-61. PMID: 16023290
- Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography. | Rosland, M., et al. 2007. Drug Dev Ind Pharm. 33: 1158-66. PMID: 17963117
- Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine. | Zuo, DY., et al. 2009. Prog Neuropsychopharmacol Biol Psychiatry. 33: 290-5. PMID: 19121361
- Effect of clozapine on neutrophil kinetics in rabbits. | Iverson, S., et al. 2010. Chem Res Toxicol. 23: 1184-91. PMID: 20553052
- Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: a histopathological study. | Zlatković, J., et al. 2014. Eur J Pharm Sci. 59: 20-30. PMID: 24768740
- [Clozapine--an atypical antipsychotic agents, its advantages and risks]. | Zvolský, P. and Hulínský, J. 1994. Cesk Psychiatr. 90: 328-40. PMID: 7859323
- Clozapine is a potent and selective muscarinic M4 receptor agonist. | Zorn, SH., et al. 1994. Eur J Pharmacol. 269: R1-2. PMID: 7895765
- Functional antagonistic properties of clozapine at the 5-HT3 receptor. | Hermann, B., et al. 1996. Biochem Biophys Res Commun. 225: 957-60. PMID: 8780717
Inhibitor of:
β-Arrestin-2, A530099J19Rik, AOX3, AOX4, CHT1, CNTNAP3, D-GPCR, D2, D2DR, D3DR, D4DR, D5DR, DARPP-32, Dysbindin 1, EG667599, encephalopsin, Gα t1, Gγ 12, Gγ 2, GPR family (GPCR;G protein-coupled), GPR115, GPR162, GPR171, GPR176, GPR61, HNMT, IGSF9, Latrophilin (ADGRL), Latrophilin-1, Latrophilin-2, MrgA5, MrgB5, Mrgprx3, MTH1, neurexin II, NPAS3, Olfr1, Olfr10, Olfr1000, Olfr1015, Olfr1018, Olfr1030, Olfr1039, Olfr1056, Olfr1061, Olfr1098, Olfr1274, Olfr3, Olfr341, Olfr655, Olfr735, Olfr736, Olfr738, Olfr884, Olfr94, Olfr951, Olfr959, Olr831, OR1S1, OR2C1, OR2D2, OR2M, OR3A1, OR4D10, OR4X2, OR5K1, OR6B1, R7BP, Regulator of G protein signaling (RGS), RGS16, Rit2, SC, SEZ6, Snf1, SR-1E, SR-1F, SR-2A, SR-2B, SR-2C, SR-6, SR-7, SRA, SV2C, TAAR4, TAAR7H, TAAR9, TMEM60, V1RB2, V1RB5, V1RB9, V1rg10, V1RI5, V1RI7, Vmn1r101, Vmn1r104, Vmn1r123, Vmn1r132, Vmn1r135, Vmn1r142, Vmn1r60, Vmn2r110, Vmn2r116, Vmn2r118, Vmn2r121, Vmn2r24, Vmn2r34, Vmn2r35, Vmn2r37, Vmn2r39, Vmn2r43, Vmn2r53, Vmn2r69, Vmn2r96, VN1R2, ZCCHC17, and ZNF804A.Activator of:
ACAT-3, Centaurin γ3, CYP2A6, Cyp4f40, D2DR, DIRAS1, DISC-1, DRD1a, ENDOGL1, FAAP, FMO2, Histamine H4 Receptor, SR-1E, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clozapine, 50 mg | sc-200402 | 50 mg | $68.00 | |||
Clozapine, 500 mg | sc-200402A | 500 mg | $357.00 |