Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)
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Alternate Names:
PTX;Holotoxin
Application:
Pertussis Toxin (islet-activating protein) is a toxin that blocks reduction of adenylate cyclase activity
CAS Number:
70323-44-3
Purity:
≥95%
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Pertussis Toxin (islet-activating protein), a toxin that can be found in Bordetella pertussis, may act to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin (islet-activating protein) to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.
Pertussis Toxin (islet-activating protein) (CAS 70323-44-3) References
- Pertussis toxin and target eukaryotic cells: binding, entry, and activation. | Kaslow, HR. and Burns, DL. 1992. FASEB J. 6: 2684-90. PMID: 1612292
- Effects of lithium ion on ADP ribosylation of inhibitory GTP-binding protein by pertussis toxin, islet-activating protein. | Kawamoto, H., et al. 1991. Eur J Pharmacol. 206: 33-7. PMID: 1906007
- Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein. | Xu, J. and Wojcik, WJ. 1986. J Pharmacol Exp Ther. 239: 568-73. PMID: 2430096
- Evidence for a pertussis toxin-sensitive G protein involved in the control of meiotic reinitiation of Xenopus laevis oocytes. | Pellaz, V. and Schorderet-Slatkine, S. 1989. Exp Cell Res. 183: 245-50. PMID: 2661247
- Structure-activity analysis of the activation of pertussis toxin. | Kaslow, HR., et al. 1987. Biochemistry. 26: 123-7. PMID: 3030399
- Pertussis toxin alters the growth characteristics of Swiss 3T3 cells. | Hildebrandt, JD., et al. 1986. FEBS Lett. 203: 87-90. PMID: 3087783
- Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells. | Clark, MA., et al. 1986. Proc Natl Acad Sci U S A. 83: 7320-4. PMID: 3094005
- Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. | Bokoch, GM. and Gilman, AG. 1984. Cell. 39: 301-8. PMID: 6094010
- Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase. | Aktories, K., et al. 1983. Naunyn Schmiedebergs Arch Pharmacol. 324: 196-200. PMID: 6140642
- Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. | Tamura, M., et al. 1982. Biochemistry. 21: 5516-22. PMID: 6293544
- Identification of the predominant substrate for ADP-ribosylation by islet activating protein. | Bokoch, GM., et al. 1983. J Biol Chem. 258: 2072-5. PMID: 6296122
- Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein). | Moss, J., et al. 1983. J Biol Chem. 258: 11879-82. PMID: 6311827
- Induction of a novel morphological response in Chinese hamster ovary cells by pertussis toxin. | Hewlett, EL., et al. 1983. Infect Immun. 40: 1198-203. PMID: 6682833
Inhibitor of:
β-defensin 46, β-defensin 48, 2610528A11Rik, A530099J19Rik, cAMP, Cdc35, CKR-10, CXCL13, D-GPCR, D830046C22Rik, Dear, DGK-ι, EG331493, EG433107, EG436049, EG665186, EG667292, EMR2, EMR3, Fpr-rs6, Gα 14, Gα 15, Gα i-1, Gα i-2, Gα i-3, Gα o, Gα t2, Gβ 5, Gγ 10, Gγ 11, Gγ 13, Gγ 5, Gγ 9, Gγ4, GAIP, Gm14496, GNGT2, GPA-16, Gpa2, GPB5, GPR family (GPCR;G protein-coupled), GPR101, GPR112, GPR115, GPR123, GPR128, GPR133, GPR139, GPR144, GPR155, GPR178, GPR179, GPR41, GPR61, HM74A, INTS5, L-Selectin, Lipocalin-14, LOC388564, MAS1, MrgA5, MrgB3, MrgB5, MrgB8, Mrgprx3, MUP21, MUP7, MUP8, MUP9, Olfr1008, Olfr1015, Olfr1020, Olfr1037, Olfr1047, Olfr1048, Olfr1055, Olfr1061, Olfr1062, Olfr1079, Olfr108, Olfr1080, Olfr1086, Olfr1090, Olfr1093, Olfr1115, Olfr1274, Olfr1458, Olfr339, Olfr371, Olfr373, Olfr437, Olfr441, Olfr446, Olfr447, Olfr463, Olfr464, Olfr466, Olfr467, Olfr485, Olfr486, Olfr487, Olfr488, Olfr495, Olfr497, Olfr498, Olfr5, Olfr50, Olfr502, Olfr503, Olfr51, Olfr564, Olfr566, Olfr569, Olfr612, Olfr631, Olfr713, Olfr715, Olfr716, Olfr723, Olfr724, Olfr725, Olfr726, Olfr727, Olfr728, Olfr747, Olfr776, Olfr777, Olfr779, Olfr780, Olfr781, Olfr782, Olfr784, Olfr818, Olfr819, Olfr837, Olfr850, Olfr869, Olfr870, Olfr876, Olfr877, Olfr878, Olfr888, Olfr890, Olfr891, Olfr893, Olfr894, Olfr895, Olfr898, Olfr899, Olfr900, Olfr901, Olfr902, Olfr907, Olfr908, Olfr909, Olfr91, Olfr910, Olfr912, Olfr913, Olfr914, Olfr915, Olfr916, Olfr917, Olfr918, Olfr919, Olfr92, Olfr921, Olfr923, Olfr924, Olfr926, Olfr93, Olfr936, Olfr974, Olfr975, Olfr993, Olfr994, Olfr995, Olfr996, Olfr998, Olr831, OR10H1, OR1A2, OR1J2, OR1S1, OR1S2, OR2AT4, OR2C1, OR4C16, OR4C3, OR4D1, OR4K15, OR5B3, OR5M3, OR6B1, OR9A4, PDCL3, Regulator of G protein signaling (RGS), RGS1, RGS16, RGS20, RGS21, RGS22, RIC-8A, RIC-8B, Ste4, T2R04, T2R21, TAAR4, Tas2r103, Tas2r125, TMEM154, TMEM248, V1RB2, V1rc31, V1RI5, Vmn1r104, Vmn1r115, Vmn1r119, Vmn1r12, Vmn1r123, Vmn1r126, Vmn1r129, Vmn1r139, Vmn1r143, Vmn1r149, Vmn1r15, Vmn1r158, Vmn1r160, Vmn1r161, Vmn1r168, Vmn1r169, Vmn1r17, Vmn1r173, Vmn1r184, Vmn1r196, Vmn1r20, Vmn1r30, Vmn1r34, Vmn1r60, Vmn1r61, Vmn1r86, Vmn1r88, Vmn2r1, Vmn2r110, Vmn2r118, Vmn2r18, Vmn2r43, Vmn2r53, Vmn2r71, Vmn2r73, Vmn2r84, Vmn2r96, and XCR1 (X-C motif chemokine receptor 1).Activator of:
CKR-7, Cya A, cytohesin-1, EG432838, EG436049, eRF3b, EXOSC9, fractalkine, Gα gust, Gα t1, Gα t12, Gγ 1, Gγ 3, Gγ 7, GNA1, Gpa1, GPR110, GPR113, GPR137C, GPR148, GPR162, GPR171, GPR89A, GPSM3, GPSN2, GRIN3, GRTP1, GSG1, mPRδ, Olfr1012, Olfr1061, Olfr1099, Olfr3, Olfr301, Olfr544, OR11H1, OR11HOR11H12, OR13C5, OR13D1, OR2C1, OR2G6, OR3A3, OR4C45, OR8J3, ORNT1, ORNT2, PIG-L, Pigr, Placental lactogen Iβ, PNMA6E, Raver1, RFX3, RGS11, RGS14, RGS3, RICS, SC, SGSM1, SREB3, T2R29, V1RA2, V1RE10, V1RE11, V1RG1, V1RG11, V1RG12, V1RG2, V1RG3, V1RG4, V1RH14, Vmn1r114, Vmn2r18, Vmn2r19, Vmn2r2, Vmn2r20, Vmn2r21, Vmn2r22, Vmn2r26, Vmn2r27, Vmn2r28, Vmn2r3, Vmn2r30, Vmn2r31, Vmn2r32, and Vmn2r33.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pertussis Toxin (islet-activating protein), 50 µg | sc-200837 | 50 µg | $451.00 |