Molecular structure of L-Noradrenaline, CAS Number: 51-41-2
L-Noradrenaline (CAS 51-41-2)
See product citations (3)
Alternate Names:
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; L-Arterenol; L-Noradrenaline; Levarterenol
Application:
L-Noradrenaline is an adrenergic neurotransmitter
CAS Number:
51-41-2
Purity:
≥95%
Molecular Weight:
169.18
Molecular Formula:
C8H11NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Noradrenaline, released by the adrenal medulla, functions as both a hormone and a neurotransmitter. It exhibits vasoconstrictor and bronchodilator effects, along with other actions like raising metabolic rate and blood pressure. Binding to β-adrenergic receptors on cells, L-Noradrenaline prompts the release of cyclic adenosine monophosphate (cAMP), which triggers protein kinase A activation. Consequently, phosphorylated proteins result in increased cell activity. Moreover, the binding of L-Noradrenaline to β-adrenergic receptors activates voltage-dependent calcium channels, heightening calcium ion permeability. This elevation of intracellular calcium ions induces muscle contraction and relaxation of smooth muscles in various organs. In vitro studies related to L-Noradrenaline typically involve measuring its levels in culture medium or isolated cells, employing techniques like ELISA or HPLC. These studies shed light on L-Noradrenaline′s involvement in diverse cellular processes, including gene expression and cell signaling.
L-Noradrenaline (CAS 51-41-2) References
- On the racemization of L-noradrenaline bitartrate. | El-Nimr, AE., et al. 1975. Pharmazie. 30: 216-7. PMID: 1153485
- Influence of dibenamine and piperidono-methyl-benzodioxane (933F) upon the effect of 1-adrenaline and l-noradrenaline on the isolated rat heart. | SERIN, F. 1952. Acta Physiol Scand. 26: 299-311. PMID: 13007486
- The effect of ganglion block and L-noradrenaline on the blood pressure of normal and hypertensive rabbits. | CONWAY, J. 1954. J Physiol. 125: 33-4P. PMID: 13192794
- The behaviour of the blood pressure in normal and hypertensive rabits in response to L-noradrenaline and to ganglion block by hexa- or pentamethonium. | CONWAY, J. 1955. J Physiol. 127: 69-80. PMID: 14354628
- The terminal stages of Plasmodium knowlesi infection in Macaca mulatta. II. The pharmacological action of L-noradrenaline and adrenaline. | MAEGRAITH, BG., et al. 1959. Ann Trop Med Parasitol. 53: 369-79. PMID: 14419716
- The inhibitory action of noradrenaline and other monoamines on spinal neurones. | Engberg, I. and Ryall, RW. 1966. J Physiol. 185: 298-322. PMID: 16992224
- Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. | Martínez, A., et al. 1990. Eur J Biochem. 193: 211-9. PMID: 2226440
- L-noradrenaline functionalized near-infrared fluorescence CdSeTe probe for the determination of urea and bioimaging of HepG2 Cells. | Li, Z., et al. 2017. Talanta. 171: 16-24. PMID: 28551123
- Inhibitory effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in the caudate nucleus. | Hirose, A., et al. 1988. Jpn J Pharmacol. 48: 435-40. PMID: 2907593
- Pulmonary extraction of circulating noradrenaline in man. | Henriksen, JH., et al. 1986. Eur J Clin Invest. 16: 423-7. PMID: 3100310
- Paradoxical effects of acidosis on the noradrenaline-induced and neurogenic constriction of the rat tail artery at low temperatures. | Yartsev, VN. 2021. Can J Physiol Pharmacol. 99: 1036-1047. PMID: 33857387
- PAMAM-Calix-Dendrimers: Second Generation Synthesis, Fluorescent Properties and Catecholamines Binding. | Mostovaya, O., et al. 2022. Pharmaceutics. 14: PMID: 36559243
- Suppression of exploratory locomotor activity by the local application of dopamine or l-noradrenaline to the nucleus accumbens of the rat. | Svensson, L. and Ahlenius, S. 1983. Pharmacol Biochem Behav. 19: 693-9. PMID: 6647505
- Functional importance of nucleus accumbens noradrenaline in the rat. | Svensson, L. and Ahlenius, S. 1982. Acta Pharmacol Toxicol (Copenh). 50: 22-4. PMID: 7064714
Inhibitor of:
B230216G23Rik, beta1-AR, Olr242, Olr34, ORCTL2, PPP1R1C, and TAAR7E.Activator of:
α1D-AR, α1A-AR, α1B-AR, α2B-AR, α2C-AR, δ-sarcoglycan, A1, A530099J19Rik, AbdA, ACTC1, ACY1L2, ADM Receptor, ADNP, AIDA-1, alpha2A-AR, Angiotensinase C, AP1AR, B230216G23Rik, BAALC, BOLA2, BRI3BP, BTBD3, BTG3, C8orf57, CA II, CA VI, CA XV, Calponin 1, CARD 10, CELSR3, Chromozym X, COMTD1, Connexin 43, cortexin 1, CPAMD8, CREB-1, CRF-RI, dHAND, DNPEP, dNT-2, DNTNP, DNTTIP2, Doc 4, DUS3L, ECEL1, Edwardsiella tarda, EG626305, ESAM, ET, ETL, FILIP, FXYD4, Gα 15, Gα z, GalNAc-TL1, GLEPP1, Glucose, Gm14496, GMPR2, GNGT2, GnRH II, GP2, GPR110, GPR148, GPR176, GPR37L1, GPR82, GRK 4, HCN2, HCN4, HCR, Histone H2B.S, HNK-1ST, HuC, I-309, Ketohexokinase, KLKBL4, KMCP1, L-Lactate Dehydrogenase, L-type Ca++ CP β1, Latrophilin-2, LMO3, LOC257407, MAS1L, MiRP1, MRAP2, MrgA1, MrgA2, MrgA4, MrgA6, MrgA8, MrgB1, MS4A6A, Multimerin-1, MUP20, MYBPC3, MYH11, MYH6, MYL2, N-α-Benzoyl-L-arginine-4-nitranilide, Na+ CP type IIβ, Na+/K+-ATPase β2, NAGA, Naglt1a, NC2α, NCAM, NCBE, Neurexophilin-4, NHE-1, NMB, NMBR, NPT1, Obp1b, Obscurin, Olah, OLFML3, Olfr1009, Olfr1012, Olfr1018, Olfr1079, Olfr1085, Olfr1094, Olfr1458, Olfr328, Olfr329, Olfr390, Olfr393, Olfr51, Olfr510, Olfr739, Olr1104, Olr440, Olr444, Olr480, Olr483, Olr490, Olr500, Olr515, Olr517, Olr530, Olr540, Olr542, Olr554, Olr557, Olr560, Olr569, Olr577, Olr598, Olr607, Olr610, Olr614, Olr63, Olr636, Olr649, Olr655, Olr659, Olr668, OR10S1, OR13F1, OR2A1, OR4A15, OR4C46, OR4F17, OR4K13, OR5AN1, OR5AP2, OR5AR1, OR5AS1, OR5AU1, OR5B21, OR5F1, OR7G2, OR8B3, OR8H3, OTTMUSG00000002200, OTTMUSG00000002201, OTTMUSG00000002543, OTTMUSG00000007521, OTTMUSG00000007855, OTTMUSG00000008081, OTTMUSG00000008385, OTTMUSG00000008394, OTTMUSG00000011273, OTTMUSG00000016321, OX2, PATJ, PDE 3A, PDE4D, Pigr, PLB, PLC 2, PNMTase, Rap1GAP, RASL11A, Reg Iα, RFPL4, RFRP-1, RGS4, RPGRIP1L, SCGN, SG2NA, SNX10, sodium/potassium-ATPase β1, SPRED2, SSH2, syncytin-B, TAAR, TAAR5, TAAR9, TCP-c, Teneurin-3, TFIIIB, TIPUH1, TMEM16B, Trav12n-1, TRH-R1, TRH-R2, Troponin C, V1RA1, V1RA6, V1RA8, V1RB1, V1RB3, V1RB4, V1RB5, V1RB8, V1RC11, V1RC13, V1RC15, V1RC17, V1RC19, V1RC26, V1RC28, V1RD13, V1RD6, V1RE3, V1RF4, V1RG8, V1RH2, V1RH21, V1RH6, V1RH7, V1RH8, V3R 2, Vasculin, VHX, Vmn1r121, Vmn1r160, Vmn1r184, Vmn2r10, Vmn2r100, Vmn2r101, Vmn2r102, Vmn2r103, Vmn2r104, Vmn2r105, Vmn2r106, Vmn2r108, Vmn2r11, Vmn2r110, Vmn2r112, Vmn2r114, Vmn2r117, Vmn2r12, Vmn2r120, Vmn2r122, Vmn2r14, Vmn2r17, Vmn2r23, Vmn2r25, Vmn2r36, Vmn2r38, Vmn2r39, Vmn2r40, Vmn2r42, Vmn2r44, Vmn2r46, Vmn2r7, Vmn2r71, Vmn2r73, Vmn2r75, Vmn2r77, Vmn2r86, Vmn2r9, Vmn2r90, Vmn2r92, Vmn2r94, Vmn2r96, Vmn2r98, VN1R4, and VSTM3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Noradrenaline, 1 g | sc-357366 | 1 g | $320.00 | |||
L-Noradrenaline, 5 g | sc-357366A | 5 g | $475.00 |