Molecular structure of Ibuprofen, CAS Number: 15687-27-1
Ibuprofen (CAS 15687-27-1)
See product citations (6)
Alternate Names:
2-[4-(2-methylpropyl)phenyl]propanoic acid
Application:
Ibuprofen is a Cox-1 and Cox-2 inhibitor
CAS Number:
15687-27-1
Purity:
≥99%
Molecular Weight:
206.28
Molecular Formula:
C13H18O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ibuprofen inhibits Cox (cyclooxygenase) selectively, targeting Cox-1 (PGH synthase-1) with an IC50 of 13 muM, and Cox-2 (PGH synthase-2) with an IC50 of 370 muM. Ibuprofen is useful as a nonsteroidal anti-inflammatory research chemical. Ibuprofen is reported to inhibit the netrophil-dependent edema response of rabbit skin to C5a/PGE23.
Ibuprofen (CAS 15687-27-1) References
- Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin. | Santi, P., et al. 2003. Int J Pharm. 266: 69-75. PMID: 14559395
- Pharmacokinetics of the enantiomers of ibuprofen in the rabbit. | Williams, KM., et al. 1991. Agents Actions. 34: 381-6. PMID: 1810148
- Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. | Grillo, MP. and Hua, F. 2008. Chem Res Toxicol. 21: 1749-59. PMID: 18680316
- Ibuprofen ion-exchange fiber complex: improved dissolution and gastric tolerance based on ion exchange. | Che, X., et al. 2013. Drug Dev Ind Pharm. 39: 744-51. PMID: 22694127
- Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry. | Cardoso, JL., et al. 2014. J Sep Sci. 37: 944-9. PMID: 24482408
- Photodegradation of ibuprofen under UV-Vis irradiation: mechanism and toxicity of photolysis products. | Li, FH., et al. 2015. Bull Environ Contam Toxicol. 94: 479-83. PMID: 25680932
- Exploring the Degradation of Ibuprofen by Bacillus thuringiensis B1(2015b): The New Pathway and Factors Affecting Degradation. | Marchlewicz, A., et al. 2017. Molecules. 22: PMID: 28991215
- Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. | Rampart, M. and Williams, TJ. 1986. Biochem Pharmacol. 35: 581-6. PMID: 3081008
- Regular use of ibuprofen reduces rat penile prostaglandins and induces cavernosal fibrosis. | Elkamshoushi, AA., et al. 2022. Drug Chem Toxicol. 45: 1339-1344. PMID: 32967484
- Ibuprofen involves with the reduced expression of pelD and pelF in pathogenic Pseudomonas aeruginosa strains. | Rastgar, MG., et al. 2022. Arch Microbiol. 204: 329. PMID: 35578035
- Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction. | Myers, RF. and Siegel, MI. 1983. Biochem Biophys Res Commun. 112: 586-94. PMID: 6221723
- Disposition of ibuprofen in nephrectomized dogs. | Au, DS., et al. 1984. J Pharm Sci. 73: 705-8. PMID: 6737251
- Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. | Meade, EA., et al. 1993. J Biol Chem. 268: 6610-4. PMID: 8454631
Inhibitor of:
α-defensin 2, β-defensin 124, 3β-HSD5, 9530003J23Rik, AADAC, ABCC12, ACCN5, AGP-2, AIDA-1, AKR1C12, AKR1C13, AKR1C14, AKR1C18, AKR1C19, AKR1C20, AQP2, ASC2, ASIC-β, ASIC1, BC024978, BC049352, BPIL1, BSA, BTN3A2, BTN3A3, BTR1, C10orf115, C12orf75, C1QTNF (C1q and TNF related), C4 A, C5orf37, C6, Calgranulin A, Cd59b, CD62L ligand, CEACAM6, CLC-KB, CLEC-18B, CNG-1β, Cox-2, CRP, CRS4C-4, CTGLF, CTGLF7, CTL2, CTRP4, CysLT1 Receptor, cytohesin-4, D11Wsu47e, ENDOGL1, Enzyme, ESAM, EU599041, GDF-15, GM-CSF, Gm11062, Gm13247, Gm14139, Gm14306, Granulocyte Marker, Granulocytee Marker, group IVC sPLA2, group IVD sPLA2, GSDML, GSTM5, Histatin 2, HRSP12, IFRG15, Igkv3-4, Ik1, IL-1F8, IL-1R8, IL-8RA, KNAT1, KV1.5, LOC729083, LPLUNC1, LPLUNC3, LTB4DH, LZIP, MDA-7, MrgB2, MRGE, NALP11, Ninjurin-1, OAT2, OAT3, OAT6, ODR4, Olfr251, Olfr310, Olfr33, Olfr342, Olfr356, Olfr376, Olfr38, Olfr427, Olfr639, Olfr666, Olfr74, Olfr740, Olfr741, Olfr742, Olfr744, Olfr745, Olfr746, Olfr822, Olfr823, Olr437, OPLAH, OR2T3, OR2W3, PAF acetylhydrolase 2, PF-4, PGAM2, PGD synthase, PGE Synthase, PGE synthase 2, PGS1, PGT, PLP-Cγ, PSG1, Ptx3, retbindin, SAA3, SCP2, Serglycin, SerpinA9, SerpinB9e, SIMP, SLC17A4, SLC22A11, Slc22a27, SLC22A9, SLC26A3, SLC4A7, SPLUNC2, SPRR4, TAFA2, TMEM117, TMEM16J, TMPRSSs8, TREML2, TSARG4, UGRP1, UGT1A8, YKL-39, and Ym1.Activator of:
ABCD4, ABO Blood Group Antigens, AKR1C19, AKR1C6, AKR7A4, APP, AQP12A, ARG-Vasopressin, ASIC4, Asporin, Bestrophin-1, Blr1, BPIL2, Brucella abortus LPS, C1INH, C1qL4, C4 A, CD35_Curry, CEACAM19, Chemokine Receptor D6, CRIP1, Cyp2c39, CYP2C9, CysLT1, DD1, EBV Ea-R p85, EPX, Gem, GPR137C, GPR82, H2-Q10, ICAM-2, IL-1F9, IL-1RII, JMJD7-PLA2G4B, KCNG1, KCNG2, LBP, LBP1, Lewis Blood Group Antigen, MAdCAM-1, MASGP-BP, MCP-3, MNS Blood Group Antigens, MRFAP1L1, MRP4, NFKBIL2, NHERF-1, Nlrp12, OLFML3, Olr1052, Olr1060, Olr1063, Olr1065, Olr1076, Olr110, Olr111, Olr1124, Olr1126, Olr113, Olr1149, Olr1169, Olr1203, Olr1206, Olr1220, Olr1228, Olr1231, Olr1235, Olr125, Olr1259, Olr1286, Olr1292, OR5AP2, PIEZO1, RNF31, SerpinA1f, SerpinA3b, SerpinB11, SerpinB6, SIGIRR, Slo3, SLPI, TG1019, TMEM150C, TXA synthase, and V1rg10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ibuprofen, 1 g | sc-200534 | 1 g | $53.00 | |||
Ibuprofen, 5 g | sc-200534A | 5 g | $88.00 |