GPR128 Inhibitors
GPR128 inhibitors are a class of chemical agents that specifically target and impede the function of the G protein-coupled receptor 128 (GPR128). GPR128 is part of a large and diverse family of cell surface receptors that respond to a variety of external stimuli and activate intracellular signal transduction pathways. The inhibitors designed for GPR128 are conceived through meticulous research and development processes that involve the study of the receptor's ligand-binding domain and the subsequent design of molecules that can effectively obstruct the receptor's natural ligand from binding or initiating a cellular response. These inhibitors are often characterized by their high specificity and affinity for GPR128, ensuring that they can selectively interact with the receptor without substantially affecting other G protein-coupled receptors with similar structures.
In the development of GPR128 inhibitors, chemists and researchers employ various techniques such as computer-aided drug design and high-throughput screening to identify potential inhibitory compounds. This often involves modeling the molecular structure of GPR128 and simulating how different molecules may interact with it. Once potential inhibitors are identified, they undergo a series of modifications to enhance their binding efficiency and selectivity for GPR128. The structural makeup of these inhibitors is typically complex, with specific functional groups arranged to optimize interactions with key amino acid residues within the receptor's binding pocket.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
An inhibitor of Gαi and Gαo proteins, which can modulate the signaling of GPCRs, potentially affecting GPR128 signaling downstream. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $500.00 | ||
Specific inhibitor of the Gq family. By blocking Gq signaling, it can indirectly modulate the potential downstream effects of GPR128 if it signals via this pathway. | ||||||
NF 023 | 104869-31-0 | sc-204124 sc-204124A | 10 mg 50 mg | $158.00 $617.00 | 1 | |
A selective inhibitor of Gαs protein. If GPR128 utilizes Gαs for its signaling, this compound can indirectly influence its activity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
Cdc42 GTPase inhibitor which can influence GPCR downstream effects related to actin reorganization. If GPR128's downstream signaling affects actin dynamics, this inhibitor can modulate its activity. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
Adenylyl cyclase inhibitor. By inhibiting adenylyl cyclase, it can modulate cAMP production, which is downstream of some GPCRs. If GPR128 signaling involves cAMP modulation, SQ 22,536 can influence its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor. Many GPCRs signal via the PI3K-Akt pathway, and if GPR128 is one of them, this inhibitor can play a role in modulating its signaling outcomes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An ERK pathway inhibitor. If GPR128 signals through the ERK pathway, this compound can modulate its signaling effects. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator. By chelating intracellular calcium, it can influence GPCR pathways that rely on calcium signaling. If GPR128 induces calcium fluxes, this compound can modulate its effects. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
A non-selective beta-adrenergic receptor antagonist. If GPR128 has any crosstalk or interactions with beta-adrenergic receptors, this drug can influence its signaling. | ||||||
PD 116,948 | 102146-07-6 | sc-200115 sc-200115A | 25 mg 100 mg | $122.00 $224.00 | 6 | |
An adenosine A1 receptor antagonist. If there's crosstalk between GPR128 and adenosine receptors, this compound can indirectly modulate GPR128's effects. | ||||||