Molecular structure of ML 141, CAS Number: 71203-35-5
ML 141 (CAS 71203-35-5)
See product citations (7)
Alternate Names:
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
Application:
ML 141 is a potent Cdc42 GTPase inhibitor
CAS Number:
71203-35-5
Purity:
≥98%
Molecular Weight:
407.49
Molecular Formula:
C22H21N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ML 141 is a selective, potent and reversible non-competitive inhibitor Cdc42, a Rho family GTPase member. Cdc42 is involved in the control of actin polymerization by directly interacting with Neural Wiskott-Aldrich syndrome protein (N-WASP), which in turn activates the Arp2/3 complex. This complex plays a role in the formation of branched actin networks and regulates key cellular processes such as cell adhesion, cytoskeletal organization, phagocytosis, host-pathogen interactions, cell motility, migration, and membrane protein trafficking.
ML 141 (CAS 71203-35-5) References
- A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells. | Kalwat, MA., et al. 2013. Biochem Pharmacol. 85: 808-16. PMID: 23246867
- Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. | Hong, L., et al. 2013. J Biol Chem. 288: 8531-8543. PMID: 23382385
- T cells sense biophysical cues using lamellipodia and filopodia to optimize intraluminal path finding. | Song, KH., et al. 2014. Integr Biol (Camb). 6: 450-9. PMID: 24599186
- Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus. | Cordero, D., et al. 2014. Curr Pharm Biotechnol. 15: 727-37. PMID: 25213310
- Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. | Sumida, GM. and Yamada, S. 2015. J Biol Chem. 290: 3238-47. PMID: 25527498
- EIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins. | Pinzaglia, M., et al. 2015. BMC Cancer. 15: 131. PMID: 25886394
- Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway. | Huang, Z., et al. 2016. Cell Death Dis. 7: e2142. PMID: 26986510
- The effect of Rho drugs on mast cell activation and degranulation. | Sheshachalam, A., et al. 2017. J Leukoc Biol. 102: 71-81. PMID: 28411215
- Ghrelin Promotes Cortical Neurites Growth in Late Stage After Oxygen-Glucose Deprivation/Reperfusion Injury. | Liu, J., et al. 2019. J Mol Neurosci. 68: 29-37. PMID: 30806968
- Integrin crosstalk allows CD4+ T lymphocytes to continue migrating in the upstream direction after flow. | Kim, SHJ. and Hammer, DA. 2019. Integr Biol (Camb). 11: 384-393. PMID: 31851360
- Rat corneal endothelial cell migration during wound repair on the basement membrane depends more on the PI-3K pathway than the cdc-42 pathway or actin stress fibers. | Gordon, SR., et al. 2020. Cell Tissue Res. 382: 351-366. PMID: 32566981
- Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice. | Rather, IIG., et al. 2022. Environ Sci Pollut Res Int. 29: 17417-17424. PMID: 34665416
- A Potent And Selective Inhibitor Of Cdc42 Gtpase | Zurab Surviladze, et al. 2010. Probe Reports From The Nih Molecular Libraries Program.
Inhibitor of:
α-actinin-1, α-actinin-4, α-chimaerin, α1-chimaerin, αPIX, β2-chimaerin, βPAK, γ1-Adaptin, γ2-Adaptin, 2410002O22Rik, 4931406P16Rik, A430078G23Rik, ABR, ACBD3, ACTL7B, AGAP1, ANKMY2, ANKRD27, AP-4, AP-4β, AP-4σ, AP3 Adaptor Complex, Arf2, ARFGEF (BIG1, BIG2, BIG3), ARHGAP10, ARHGAP12, ARHGAP15, ARHGAP21, ARHGAP23, ARHGAP24, ARHGAP39, ARHGEF10, ARHGEF10L, ARHGEF17, ARHGEF19, ARHGEF37, ARHGEF38, ARHGEF39, ARHGEF5_Arhgef5, ARHGEF5L, ARHGEF9, ARL13A, ARL14EPL, ARL16, ARL4D, ARL5B, ARL8B, ARL9, ARNO, Atlastin, BAIAP2L2, BC055111, BET5, BRAG2, C11orf56, C20orf95, C6orf100, C9orf100, Caldesmon, CCDC38, CCDC53, Cdc42, Cdc42EP2, Cdc42EP3, Cdc42EP4, Cdc42EP5, CdGAP, Centaurin γ3, CHM Rab escort protein, CHMP1B, CIP4, COG4, COPZ, COPZ2, CTTNBP2, cytohesin-2, DBC-2, DDEFL1, DENND1A, DENND2C, DENND4C, DENND5B, DENND6B, DIAPH3, DIRAS2, DOCK 6, DOCK 7, Drac1/2, E130112L23Rik, E430025E21Rik, Ect2, EG432879, EG667543, EHBP1, EHBP1L1, Elmo1, Enzyme, EPI64, EPLIN, Esp4, EVI27, FAM109A, FAM127A, FAM160A2, FAM21A, FAM21C, FAM221B, FAM39E, FBP21, FGD6, FHOD1, Fpr-rs6, FRMD7, Gα i-2, Gα q, Gγ 10, Gγ 12, Gγ 5, GAIP, Gbp10, GBP8, Gbp9, GEF-2, GIMAP3, GIMAP9, Gm1527, Gm1966, Gm732, Gm949, GNGT2, GOLGA8A, GOLGA8G, GOLGA8J, GOLGA8R, GOLGB1, golgin 160, Gpa2, GPB5, GPR101, GPR128, GPR178, GPSM3, IGSF4D, IPCEF1, IQGAP2, IQSEC2, IQSEC3, IRSp53, ITFG2, KLHDC9, LARG, Lbc, LIN-10, LURAP1, Ly-GDI, LYPD3, MCF2L2, MICAL, MICAL1, Moesin, MON1B, MRCKγ, MrgB13, MrgB8, MTSS1, Munc13-4, Muskelin, N-cadherin, N-WASP, NCKAP5L, NET1, netrin-1, Olfr1008, Olfr1079, oligophrenin-1, ORF19, Otoferlin, OTTMUSG00000005723, PACS-1b, PACSIN3, PAK5, Pals1, PAR-6, PARD3A, PARD3B, PARD6G, PDZ-GEF1, PHLDB1, PIPK III, plakophilin 4, PLEKHG1, PLEKHG2, PLEKHG3, PLEKHG5, PLEKHG6, PLEKHH3, plexin-B2, POR1, Punctin, Rab 11A, Rab 14, Rab 16, Rab 23, Rab 27b, Rab 2A, Rab 30, Rab 32, Rab 38, Rab 3A, Rab 3C, Rab 43, Rab 4B, Rab 5A, Rab 5B, Rab 6, Rab 6A, Rab 7L1, Rab 9A, Rab 9B, Rab GDI (GDP dissociation inhibitor), Rab11-FIP1, Rab11-FIP2, Rab11-FIP3, Rab11-FIP4, RAB3IL1, Rabaptin-5β, Rabex-5, rabphilin-11, rabphilin-3AL, Rabr, Rac 2, Rac 3, Ral A, Ral BP-1, Ral GDS, Ral GPS1, RAP1GDS1, RAPGEF5, RASA4B, REEP3, Reticulon, RGL3, RGNEF, RGS21, Rho 8, Rho G, Rho GAP p190, Rho H, Rho J, Rho T1, Rho V, RHOBTB1, RhoGEF p115_Lsc, Rhotekin, RICS, RILP, RILPL1, RILPL2, RIN3, RINL, RINT-1, RIP/Rab, RIPX, RIT (Ras-like without CAAX), Rnd1, RNF103-CHMP3, RUFY2, Sar1, Sec15B, SEC16L, SEC22A, Sec24C, SEMA6B, Septin 3, SERINC5, SFT2D3, SH3BP4, SH3TC1, Slac2-c, SLIT-ROBO Rho GTPase activating protein (SRGAP), SMAP1, SMAP1L, SNX5, Strumpellin, SUCO, SYDE1, TAAR4, TBC1D12, TBC1D13, TBC1D14, TBC1D19, TBC1D2, TBC1D21, TBC1D22B, TBC1D23, TBC1D25, TBC1D2B, TBC1D3, TBC1D30, TC10, tepsin, TGN38B, THSD4, Tiam2, TIP20, TMED8, TMEM192, TOCA-1, TRAPPC5, TRAPPC6B, TRIP6, Tropomyosin β, Unc18-2, v-SNARE Vti1a, V1RI5, Vav3, VE-cadherin, Veli1, VEPH1, vinculin, VIPAR, Vmn1r100, Vmn1r126, Vmn1r143, Vmn1r149, Vmn1r60, Vmn2r43, Vmn2r53, VPS13A, VPS45, VPS51, WAVE3, WDR26, WDR81, WRCH1, YIF1A, YIPF4, YJEFN3, ZFYVE19, ZFYVE21, ZFYVE28, Zizimin-1, and ZSCAN5.Activator of:
γ2-COP, 4931406P16Rik, A430078G23Rik, Aex-3, ARFGAP1, ARHGAP11A, ARHGAP18, ARHGAP27_Arhgap27, ARHGAP29, ARHGAP30, ARHGAP36, ARHGAP40, ARHGAP6, ARHGAP8, ARHGEF17, ARHGEF37, ARHGEF38, ARL2, ARL7, ARL8A, Arp3β, ARPC5L, Asef, BBS4, C20orf95, C3orf34_1500031L02Rik, CD9, Cdc42, CED-2, CED-5, CLTCL1, CMV gH, COPB, COPG, Coronin 6, DENND1A, DENND2A, DOCK 180, Eps8, FAM21A, FGD2, FGD5, Flightless I, FNBP3, FNDC1, Frabin, Gm600, Gm732, Gm949, GRF-1, HOOK1, Kaptin, LIMK-1, LURAP1L, MBNL1, MOB1B, MON1B, MSE55, Myosin Ic, Myosin X, NAG, PACSIN1, PACSIN2, PARD6B, PDZ-RhoGEF, PLEKHM1, plexin-A2, RAb 19B, Rab 1A, Rab 2A, Rab 33A, Rab 3D, Rab 4A, Rab 7L1, Rab L2B, Rab11-FIP5, rac1, RAM, Ran BP-4, Rho D, Rho GAP p190, Rho GAP p190-B, Rho GDIγ, Rho J, Rho V, RICH2, SAV1, SEC16L, Sec4, SEMA3D, SEPT10, SNX16, SNX18, SWAP-70, TBC1D14, TBC1D20, TC10, VPS11, VPS26B, WDR18, and WDR47.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ML 141, 5 mg | sc-362768 | 5 mg | $137.00 | |||
ML 141, 25 mg | sc-362768A | 25 mg | $512.00 |