GPR128 Activators
Chemicals classified as GPR128 activators are varied, encompassing lipid signaling molecules, components of cellular membranes, and modulators of multiple G protein signaling pathways. The functionality of GPR128 as a GPCR suggests that its activity can be regulated by alterations in cell membrane dynamics and the intricate network of GPCR-mediated signaling. Lipid-based activators like lysophosphatidic acid and sphingosine-1-phosphate, which have their own GPCR targets, may exert an influence on GPR128 through modulation of the lipid microenvironment or via signal transduction pathways that intersect with GPR128's signaling. Similarly, cholesterol's role in membrane structure and compartmentalization can affect GPR128's distribution and, consequently, its function.
Activation of various Gα-subunit-coupled receptors by specific agonists can result in changes in second messenger concentrations, such as cAMP or calcium, which in turn can modulate the activity of related GPCRs, including GPR128. Increased cAMP from Gαs activation or altered cGMP levels from nitric oxide donors can lead to a cascade of events influencing GPR128 indirectly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
A glycerophospholipid known to activate GPCRs, influencing cellular signaling that could indirectly modulate GPR128 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
A lipid signaling molecule which binds to and activates its own GPCRs, potentially altering GPR128 activity through cross-talk between signaling pathways. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Essential for maintaining membrane structure and could modulate GPR128 by influencing its distribution or function within lipid rafts. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase, increasing cAMP, which can modulate GPCR function, potentially affecting GPR128 indirectly. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Binds to its GPCRs, influencing inflammatory signaling pathways which may have crosstalk with GPR128 signaling. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Inhibits protein tyrosine phosphatases, potentially enhancing tyrosine phosphorylation-dependent signaling pathways that may modulate GPR128. | ||||||