YM 254890 (CAS 568580-02-9)
Alternate Names:
CHEMBL4288881; (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate
CAS Number:
568580-02-9
Molecular Weight:
960.10
Molecular Formula:
C46H69N7O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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YM 254890 (CAS 568580-02-9) References
- YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666. | Taniguchi, M., et al. 2003. J Antibiot (Tokyo). 56: 358-63. PMID: 12817809
- Antithrombotic and thrombolytic efficacy of YM-254890, a G q/11 inhibitor, in a rat model of arterial thrombosis. | Kawasaki, T., et al. 2003. Thromb Haemost. 90: 406-13. PMID: 12958608
- Effect of YM-254890, a specific Galphaq/11 inhibitor, on experimental peripheral arterial disease in rats. | Uemura, T., et al. 2006. Eur J Pharmacol. 536: 154-61. PMID: 16566917
- Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog. | Rensing, DT., et al. 2015. Org Lett. 17: 2270-3. PMID: 25875152
- Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein. | Zhang, H., et al. 2017. ChemMedChem. 12: 830-834. PMID: 28509439
- Structure-Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM-254890. | Xiong, XF., et al. 2019. ChemMedChem. 14: 865-870. PMID: 30790465
- Functional evidence for biased inhibition of G protein signaling by YM-254890 in human coronary artery endothelial cells. | Peng, Q., et al. 2021. Eur J Pharmacol. 891: 173706. PMID: 33152337
- Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890. | Randolph, CE., et al. 2022. J Biol Chem. 298: 102538. PMID: 36174676
- Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability. | Medcalf, MR., et al. 2023. Synthesis (Stuttg). 55: 90-106. PMID: 36644007
- Recommended Tool Compounds: Application of YM-254890 and FR900359 to Interrogate Gαq/11-Mediated Signaling Pathways. | Voss, JH. 2023. ACS Pharmacol Transl Sci. 6: 1790-1800. PMID: 38093837
Inhibitor of:
α1D-AR, A530099J19Rik, ANXA2R, ARFGAP, ARFGAP2, ARFRP1, ARL7, ARL8B, CKR-10, EFR3B, EG436049, Gα 11, Gα 12, Gα 14, Gα 15, Gα i-1, Gα i-3, Gα o, Gα s, Gα t2, Gβ 4, Gγ 10, Gγ 11, Gγ 5, Gγ 9, Gγ4, GBF1, Gm14496, GNGT2, Gpa2, GPB5, GPR family (GPCR;G protein-coupled), GPR101, GPR128, GPR139, GPR176, GPR179, GPR39, GPR61, LOC374920_6330408A02Rik, MrgB8, Mrgprx3, N4BP2, Olfr1008, Olfr1015, Olfr1061, Olfr1093, Olfr1274, Olfr438, Olfr510, Olfr711, Olfr915, Olr831, OR1A2, OR4C46, OR4K15, OR5B3, OR5M3, P2X4, P2Y2, PDE11A, PLC β4, PLC η2, Podocin, Rab 3A, RGS16, RGS20, RGS21, RGS22, RIC-8A, RIP/Rab, Ste4, TAAR4, V1RI5, Vmn1r160, Vmn2r1, Vmn2r28, Vmn2r43, Vmn2r63, and Vmn2r96.Activator of:
AVP Receptor V1a, BRDG1, Gα q, granuphilin, GRTP1, Olfr544, ORNT1, ORNT2, Rab GDI α, RAMP3, RGS14, and WDR18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YM 254890, 1 mg | sc-507356 | 1 mg | $510.00 |