Gm71 Activators
Valosin containing protein lysine (K) methyltransferase activators can influence this enzyme's activity through various biochemical pathways. For instance, compounds like Forskolin, by stimulating adenylate cyclase, boost cAMP levels, indirectly promoting PKA activation. Activated PKA can phosphorylate proteins, potentially influencing the methylation activity of Vcpkmt, as phosphorylation states can change substrate availability or enzyme interactions. Similarly, Ionomycin, through its role as a calcium ionophore, can activate CaMKs, which may phosphorylate proteins that are potential Vcpkmt substrates or regulatory factors, thus enhancing the enzyme's methyltransferase function.
Other activators work by modifying the substrate availability or the enzyme's milieu. For example, Epigallocatechin gallate (EGCG) and SAHA inhibit deacetylases, leading to increased acetylation levels of histones, which might be preferred substrates for Vcpkmt, enhancing its activity. Increased intracellular levels of SAM, a methyl group donor, directly increase Vcpkmt's methylation capabilities.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels. This can activate CaMK, which may facilitate the phosphorylation of substrates that interact with Vcpkmt, thereby enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates numerous proteins. This could result in an upregulated interaction between phosphorylated substrates and Vcpkmt, enhancing its methylation activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to an increase in overall protein phosphorylation. This hyperphosphorylated state may indirectly enhance the activity of Vcpkmt by increasing the availability of phosphorylated substrates. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits class I histone deacetylases, which potentially increases acetylation of histones. Acetylated histones may be preferred substrates for Vcpkmt, leading to enhanced methylation activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM serves as a methyl donor for methylation reactions catalyzed by methyltransferases. An increased concentration of SAM can enhance the methylation activity of Vcpkmt by providing more methyl groups for transfer. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide inhibits sirtuins, which are NAD+-dependent deacetylases. Inhibition of sirtuins can increase acetylation levels of proteins, potentially creating a more favorable substrate environment for Vcpkmt activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into RNA and DNA and inhibits DNA methyltransferases. This can lead to alterations in chromatin structure, potentially increasing the accessibility of substrates to Vcpkmt. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase inhibitor, which leads to increased acetylation of histones. Enhanced acetylation may provide an enriched substrate for Vcpkmt to act upon. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic Acid inhibits histone acetyltransferases (HATs). This can lead to a compensatory mechanism where increased methylation occurs, potentially enhancing the activity of Vcpkmt. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $271.00 $5202.00 $40368.00 $704.00 | 4 | |
Sinefungin is an inhibitor of S-adenosyl-L-homocysteine hydrolase, increasing the concentration of S-adenosyl-L-homocysteine which can act as a competitive inhibitor of SAM-dependent methyltransferases. This might lead to the feedback activation of Vcpkmt to maintain methylation equilibrium. | ||||||