Gm71 Activators

Valosin containing protein lysine (K) methyltransferase activators can influence this enzyme's activity through various biochemical pathways. For instance, compounds like Forskolin, by stimulating adenylate cyclase, boost cAMP levels, indirectly promoting PKA activation. Activated PKA can phosphorylate proteins, potentially influencing the methylation activity of Vcpkmt, as phosphorylation states can change substrate availability or enzyme interactions. Similarly, Ionomycin, through its role as a calcium ionophore, can activate CaMKs, which may phosphorylate proteins that are potential Vcpkmt substrates or regulatory factors, thus enhancing the enzyme's methyltransferase function.

Other activators work by modifying the substrate availability or the enzyme's milieu. For example, Epigallocatechin gallate (EGCG) and SAHA inhibit deacetylases, leading to increased acetylation levels of histones, which might be preferred substrates for Vcpkmt, enhancing its activity. Increased intracellular levels of SAM, a methyl group donor, directly increase Vcpkmt's methylation capabilities.