Geminin Inhibitors
Geminin inhibitors represent a class of chemical compounds that play a crucial role in regulating the cell cycle, specifically in the context of DNA replication and cell division. These inhibitors are designed to target a protein known as Geminin, which serves as a pivotal regulator in preventing re-replication of DNA during the cell cycle. The cell cycle is a highly orchestrated and tightly controlled process, essential for the growth, development, and maintenance of multicellular organisms. To ensure the accurate duplication of DNA, there are numerous checkpoints and control mechanisms in place. Geminin, a protein encoded by the GMNN gene, serves as one of these checkpoints.
Geminin inhibitors work by interfering with the function of Geminin, primarily by preventing its binding to Cdt1, another protein involved in DNA replication. In the absence of Geminin, Cdt1 is free to bind to proteins called minichromosome maintenance (MCM) proteins, which are essential for the initiation of DNA replication. By disrupting the Geminin-Cdt1 interaction, Geminin inhibitors indirectly promote the replication of DNA.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil inhibits thymidylate synthase, leading to DNA damage and cell cycle arrest, which may result in decreased Geminin expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By stabilizing the DNA topoisomerase I-DNA complex, Camptothecin causes DNA breaks, disrupting the cell cycle and potentially reducing Geminin levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates DNA and inhibits RNA polymerase, which could lead to suppressed transcription of the Geminin gene. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts, leading to DNA damage and affecting cell cycle progression, possibly lowering Geminin production. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates DNA and inhibits topoisomerase II, causing DNA damage and potentially downregulating Geminin expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, leading to DNA breaks and potentially disrupting Geminin expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, affecting nucleotide synthesis and potentially decreasing Geminin levels. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases, disrupting the cell cycle and possibly leading to lowered Geminin production. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib inhibits PARP, playing a role in DNA repair pathways, and its activity might lead to altered Geminin expression levels. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor, disrupting the cell cycle, which could in turn affect Geminin expression. | ||||||