Geminin Activators
Geminin activators refer to a group of compounds or molecules that positively modulate the activity of Geminin, a protein known for its role in DNA replication and cell cycle regulation. Geminin was first identified in Xenopus egg extracts and has since been studied extensively in various eukaryotic systems. The protein operates as a key regulator in the initiation of DNA replication by binding and inhibiting the activity of Cdt1, another protein essential for the licensing of DNA replication origins. By preventing the re-replication of DNA within a single cell cycle, Geminin ensures the genomic stability and integrity of cells. Its level fluctuates throughout the cell cycle, being absent during the G1 phase and accumulating during the S, G2, and M phases. This fluctuation is vital for the timely progression and coordination of the cell cycle.
Molecules that fall under the class of Geminin activators typically enhance the action or stabilization of the Geminin protein. Their mode of action might involve increasing the expression of Geminin, promoting its stability, enhancing its binding affinity to Cdt1, or even preventing its degradation. The study of these activators is of profound significance in understanding cellular proliferation and its intricacies. A deep comprehension of Geminin activators can offer insights into the molecular mechanics of the cell cycle, especially the replication process. Given the pivotal role that Geminin plays in preserving genomic fidelity, the elucidation of the biochemical properties, interactions, and regulatory mechanisms of Geminin activators is essential for a comprehensive understanding of cell cycle regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, is involved in cellular differentiation. Its role in inducing Geminin expression is likely linked to its ability to promote cell differentiation and progression through the cell cycle. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels in cells. This can influence various cellular processes, including cell cycle progression, potentially inducing Geminin expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can influence gene expression by altering chromatin structure. Its potential to induce Geminin could be tied to these epigenetic modifications. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, like sodium butyrate, is a histone deacetylase inhibitor. Its role in inducing Geminin expression might be through changes in chromatin accessibility and gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can alter gene expression patterns by affecting DNA methylation. This might lead to the induction of genes involved in the cell cycle, including Geminin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, has multiple cellular effects, including influence on cell cycle and apoptosis. Its potential to induce Geminin could be related to its role in cell cycle modulation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that affects a variety of cellular processes. Its influence on Geminin expression might be tied to its broader effects on cell cycle and cellular stress responses. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis. The cellular response to this may involve the induction of Geminin to ensure proper cell cycle progression. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Mimosine, an amino acid derivative, can halt cell cycle progression. The cell's response to mimosine exposure may involve Geminin induction to ensure genome stability. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin inhibits DNA polymerase and affects DNA replication. The potential induction of Geminin in response to aphidicolin could be a cellular attempt to regulate DNA replication processes. | ||||||