GBDR1 Activators

UBAC1 activators primarily function by influencing parallel or upstream pathways that render UBAC1's roles in polyubiquitination and proteasome-mediated degradation more critical. Specifically, proteasome inhibitors like MG-132 and Velcade increase the accumulation of polyubiquitinated proteins, thereby heightening UBAC1's role in their transfer to the 26S proteasome for degradation. Similarly, compounds such as Palbociclib and Olomoucine that arrest the cell in the G1 phase indirectly expand UBAC1's role in CDKN1B degradation, a process essential for cell cycle progression.

NF-κB pathway inhibitors, including JSH-23 and BAY 11-7082, restrain NF-κB activation by blocking specific steps like nuclear translocation or IκBα phosphorylation. These inhibitors indirectly underline UBAC1's role in promoting the maturation of the NFKB1 p105 precursor, which is crucial for functional NF-κB formation. In summary, UBAC1 activators act to create cellular conditions that make UBAC1's actions more essential, either by increasing the cellular need for proteasomal degradation or by modulating key signaling pathways in which UBAC1 plays a regulatory role.