Rottlerin CAS: 82-08-6
MF: C30H28O8
MW: 516.54

Rottlerin (CAS 82-08-6)

Rottlerin | CAS 82-08-6 is rated 5.0 out of 5 by 2.
  • y_2021, m_6, d_21, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.17
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3550, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 129ms
  • REVIEWS, PRODUCT
loading
5
2
4
0
3
0
2
0
1
0
Alternate Names: Rottlerin is also known as Mallotoxin.
Application: Rottlerin is a widely-used selective inhibitor of PKCδ, CAM kinase III, and a wide range of protein kinases including PRAK and MAPKAP-K2.
CAS Number: 82-08-6
Purity: ≥95%
Molecular Weight: 516.54
Molecular Formula: C30H28O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

Rottlerin is a principal phenolic compound of the Kamala plant Mallotus philippinensis. Rottlerin is a widely-used selective inhibitor of protein kinase Cδ (PKCδ) (IC50=3-6µM). Rottlerin also inhibits PKCα, PKCβ, PKCγ, PKCε, PKCη, PKCζ and CaM kinase III (IC50 = 5.3 µM). In HT1080 human fibrosarcoma cells, Rottlerin induces apoptosis and autophagy via a PKCδ-independent pathway. When tested on hERG (human Ether-á-go-go) channels, Rottlerin increased both step and tail hERG current by leftward shifting the voltage and dependence of hERG activation and slowing channel deactivation.


References

1. Gschwendt, M., et al. 1984. Cancer Lett. 25: 177-185. PMID: 6509437

2. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199: 93-98. PMID: 8123051

3. Gschwendt, M., et al. 1994. FEBS Lett. 338: 85-88. PMID: 8307162

4. Zeng, H., et al. 2006. J. Pharmacol. Exp. Ther. 319: 957-962. PMID: 16928897

5. Song, K.S., et al. 2008. Autophagy. 4: 650-658. PMID: 18424913

6. Balgi, A.D., et al. 2009. PLoS ONE. 4: e7124. PMID: 19771169

7. Yin, S., et al. 2010. J Cell Biochem. PMID: 20665667

Physical State :
Solid
Derived From :
Mallotus philippinensis
Solubility :
Soluble in ethanol (1 mg/ml), DMSO (30 mg/ml), DMF, ether, chloroform, benzene, and ethyl acetate. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
200° C
Boiling Point :
~800.44° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68
IC50 :
PKCδ: IC50 = 3-6 µM; PKCα: IC50 = 30-42 µM; PKCβ: IC50 = 30-42 µM; PKCγ: IC50 = 30-42 µM; PKCε: IC50 = 80-100 µM; PKCη: IC50 = 80-100 µM; PKCζ: IC50 = 80-100 µM; PRAK: IC50 = 1.9 µM; MAPKAP-K2: IC50 = 5 µM; CaM kinase III: IC50 = 5.3 µM
Ki Data :
PKCα: Ki= 30 µM; PKCβ: Ki= 42 µM; PKCγ: Ki= 40 µM; PKCδ: Ki= 3-6 µM; PKCε: Ki= 100 µM; PKCλ: Ki= 100 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AM6913800
PubChem CID :
Merck Index :
14: 8272
MDL Number :
MFCD00017361
EC Number :
201-395-4
SMILES :
CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Rottlerin (CAS 82-08-6)  Product Citations

See how others have used Rottlerin (CAS 82-08-6). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 43 total

PMID: # 30982662  Moreau, HD. et al. 2019. Dev. Cell. 49: 171-188.e5.

PMID: # 29522984  Wang, R. et al. 2018. Virology. 518: 172-183.

PMID: # 30168902  Liu, L. et al. 2018. Cancer Sci. 109: 3611-3622.

PMID: # 29220720  Weng, Y. et al. 2018. Int. Immunopharmacol. 55: 28-37.

PMID: # 28801242  Gonnella, R. et al. 2017. Free Radic. Biol. Med. 112: 327-335.

PMID: # 27667474  Yang, T. et al. 2017. Endocr. J. 64: 15-26.

PMID: # 28983628  Zhou, T. et al. 2017. Mol Med Rep. 16: 8513-8519.

PMID: # 29383184  Lee, KH. et al. 2017. Oncotarget. 8: 115596-115608.

PMID: # 26995094  Zielinski, J. et al. 2016. Nanomedicine. 12: 1603-13.

PMID: # 27313531  Xiao, F. et al. 2016. Front Pharmacol. 7: 146.

Citations 1 to 10 of 43 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 115ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from No comment No comment
Date published: 2015-03-31
Rated 5 out of 5 by from Rottlerin Rottlerin, a PKC inhibitor purchased from SCBT, was used to eliminate the epitope specifically recognized by the Mono-P-TBLR1 antibody (PubMed ID 18374649). -SCBT Publication Review
Date published: 2015-03-31
  • y_2021, m_6, d_21, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.17
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3550, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT