Molecular structure of Rottlerin, CAS Number: 82-08-6
Rottlerin (CAS 82-08-6)
See product citations (51)
Alternate Names:
Rottlerin is also known as Mallotoxin.
Application:
Rottlerin is a widely-used selective inhibitor of PKCδ, CAM kinase III, and a wide range of protein kinases including PRAK and MAPKAP-K2.
CAS Number:
82-08-6
Purity:
≥95%
Molecular Weight:
516.54
Molecular Formula:
C30H28O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rottlerin is a polyphenolic compound initially identified as a potent and selective inhibitor of protein kinase C delta (PKCδ). Its role in research has expanded as it has been observed to affect various other kinases and cellular targets, making it a compound of interest in studies on signal transduction and cellular regulation. In particular, rottlerin is employed to probe the functions of PKCδ in processes like apoptosis, autophagy, and the regulation of mitochondrial function. Its application in research helps to dissect the pathways where PKCδ is a critical regulator, offering insights into how modulation of this kinase may affect cell survival, proliferation, and differentiation. Additionally, rottlerin has been used to explore the mechanisms underlying inflammatory responses and cancer cell growth.
Rottlerin (CAS 82-08-6) References
- Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator. | Zeng, H., et al. 2006. J Pharmacol Exp Ther. 319: 957-62. PMID: 16928897
- Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. | Song, KS., et al. 2008. Autophagy. 4: 650-8. PMID: 18424913
- Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. | Balgi, AD., et al. 2009. PLoS One. 4: e7124. PMID: 19771169
- Rottlerin: bases for a possible usage in psoriasis. | Maioli, E. and Valacchi, G. 2010. Curr Drug Metab. 11: 425-30. PMID: 20540694
- Protein kinase CDelta and caspase-3 modulate TRAIL-induced apoptosis in breast tumor cells. | Yin, S., et al. 2010. J Cell Biochem. 111: 979-87. PMID: 20665667
- Rottlerin and cancer: novel evidence and mechanisms. | Maioli, E., et al. 2012. ScientificWorldJournal. 2012: 350826. PMID: 22272173
- Rottlerin and curcumin: a comparative analysis. | Maioli, E., et al. 2012. Ann N Y Acad Sci. 1259: 65-76. PMID: 22758638
- Non-conventional rottlerin anticancer properties. | Maioli, E., et al. 2018. Arch Biochem Biophys. 645: 50-53. PMID: 29545132
- Tumor suppressive role of rottlerin in cancer therapy. | Ma, J., et al. 2018. Am J Transl Res. 10: 3345-3356. PMID: 30662591
- The Mosaic of Rottlerin: The Sequel. | Hong, KKC., et al. 2019. J Nat Prod. 82: 1190-1199. PMID: 31017784
- Rottlerin, BDNF, and the impairment of inhibitory avoidance memory. | Huang, WL., et al. 2021. Psychopharmacology (Berl). 238: 421-439. PMID: 33146738
- Rottlerin plays an antiviral role at early and late steps of Zika virus infection. | Zhou, S., et al. 2022. Virol Sin. 37: 685-694. PMID: 35934227
- The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion. | Gschwendt, M., et al. 1984. Cancer Lett. 25: 177-85. PMID: 6509437
- Rottlerin, a novel protein kinase inhibitor. | Gschwendt, M., et al. 1994. Biochem Biophys Res Commun. 199: 93-8. PMID: 8123051
- Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. | Gschwendt, M., et al. 1994. FEBS Lett. 338: 85-8. PMID: 8307162
Inhibitor of:
α-Syntrophin, β2-Adaptin, 1700062C10Rik, ABHD5, Calpactin, Chk2, cPKC γ, DGK-κ, Doc2g, eEF2K, EG210155, EMR2, FIT2, GGA1, GPAT2, hCG_1645220, IRF-1, KCNMB2, KLRH1, LCE1C, LCE2A, MAPKAPK-2, MCEE, ME2, MSK1, nPKC θ, nPKC ζ, NRADD, p60TRP, PC-PLD1, PC-PLD2, PC-PLD2C, PCDH19, Pim-3, PITPβ, PKA Iβ, PKC, PKC δ, PKC η, PKC θ, PKC ζII, PKC beta, PKC theta, PKC-d2, PKN, PLC ε, Plk, PLSCR5, PNUTS, PRAK, PRKCDBP, RFX-B, RLBP1L2, rnk, Ser/Thr Protein Kinase, SERINC5, SRPK1, syncytin, tetranectin, TM4SF18, transgelin-2, V3R 11, V3R 4, Vmn1r224, ZIP, and ZPBP2.Activator of:
ADAM2, AIP1, AK5, AMPK, ARMC12, BC016579, caspase-9, CPI-17, DAPLE, DJ-1, EAPP, EG627853, EI24, GBDR1, Gbp9, HCC-4, HEATR3, HERG, hnRNP M, IL-17RE, Lad, LDHA, LDHB, LRRFIP1, MARCKSL1, MCPyV large T-antigen, MNSF-β, NDRG3, NF90, Nrdp1, Pallidin, PKNβ, POGK, Pre-TCRα, Pumilio 1, RBM10, Sar1B, SGK, SIRP-β2, Tom20, TRAP95, Trav3d-2, TRM61, TWIK-2, V-ATPase G3, VDAC2, and VibH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rottlerin, 10 mg | sc-3550 | 10 mg | $82.00 | |||
Rottlerin, 25 mg | sc-3550B | 25 mg | $163.00 | |||
Rottlerin, 50 mg | sc-3550A | 50 mg | $296.00 | |||
Rottlerin, 1 g | sc-3550C | 1 g | $2050.00 | |||
Rottlerin, 5 g | sc-3550D | 5 g | $5110.00 | |||
Rottlerin, 20 g | sc-3550E | 20 g | $16330.00 |