GADD 45γ Inhibitors
The chemical class of GADD45γ Inhibitors encompasses various compounds that can potentially suppress or modulate the activation of GADD45γ, a protein involved in cellular responses to stress and DNA damage. This class includes specific inhibitors of signaling molecules within the MAPK pathway, such as PD98059, U0126, SP600125, and SB203580, which target MEK, JNK, and p38 MAPK, respectively. By inhibiting these kinases, these compounds can reduce the stress-induced activation of GADD45γ.
Additionally, inhibitors of other key signaling pathways, like Wortmannin and LY294002 (PI3K inhibitors), Rapamycin (mTOR inhibitor), and 17-AAG (an HSP90 inhibitor), can also influence the pathways leading to GADD45γ activation. Natural compounds with broad signaling effects, such as Curcumin, Resveratrol, Sulforaphane, and Quercetin, are included due to their potential to modulate cellular stress responses and, consequently, GADD45γ activation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A specific inhibitor of MEK, which is part of the MAPK pathway. By inhibiting MEK, PD98059 may reduce the activation of pathways that lead to GADD45γ induction under stress. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, part of the stress-activated MAPK pathway. By inhibiting JNK, SP600125 could reduce stress-induced activation of GADD45γ. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A specific inhibitor of p38 MAP kinase, which is involved in cellular stress responses. SB203580 might inhibit the activation of GADD45γ by suppressing p38 MAPK signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, Wortmannin can suppress AKT signaling, potentially affecting pathways upstream of GADD45γ activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Similar to Wortmannin, LY294002 is a PI3K inhibitor that can affect AKT signaling, potentially leading to reduced activation of GADD45γ. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, Rapamycin can affect cellular stress responses, potentially inhibiting pathways leading to GADD45γ activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
While known for its anti-inflammatory properties, Curcumin can modulate various signaling pathways, potentially affecting those that lead to GADD45γ activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenol that can modulate multiple signaling pathways, including those related to stress response, potentially inhibiting GADD45γ activation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
A compound found in cruciferous vegetables known for its ability to modulate cellular stress pathways, which could include inhibition of GADD45γ activation. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
An HSP90 inhibitor, 17-AAG can disrupt several cellular signaling pathways, potentially affecting those leading to GADD45γ activation. | ||||||