GADD 45γ Inhibitors

The chemical class of GADD45γ Inhibitors encompasses various compounds that can potentially suppress or modulate the activation of GADD45γ, a protein involved in cellular responses to stress and DNA damage. This class includes specific inhibitors of signaling molecules within the MAPK pathway, such as PD98059, U0126, SP600125, and SB203580, which target MEK, JNK, and p38 MAPK, respectively. By inhibiting these kinases, these compounds can reduce the stress-induced activation of GADD45γ.

Additionally, inhibitors of other key signaling pathways, like Wortmannin and LY294002 (PI3K inhibitors), Rapamycin (mTOR inhibitor), and 17-AAG (an HSP90 inhibitor), can also influence the pathways leading to GADD45γ activation. Natural compounds with broad signaling effects, such as Curcumin, Resveratrol, Sulforaphane, and Quercetin, are included due to their potential to modulate cellular stress responses and, consequently, GADD45γ activation.