GADD 45γ Activators
The chemical class of GADD 45γ Activators encompasses a range of compounds that can potentially stimulate the activity of GADD45γ, a protein involved in the cellular response to stress, particularly DNA damage. This class includes DNA-damaging agents like Camptothecin, Etoposide, Cisplatin, Doxorubicin, and Bleomycin, which induce various types of DNA lesions, potentially leading to the activation of GADD45γ as part of the cellular DNA damage response mechanisms.
Additionally, this class incorporates compounds that inhibit DNA synthesis or replication, such as Hydroxyurea, 5-Fluorouracil, and Methotrexate, thereby inducing DNA replication stress and potentially stimulating GADD45γ activity. Chemicals that mimic the effects of UV light and ionizing radiation also fall into this category, as they can cause DNA damage and activate DNA repair pathways involving GADD45γ. Nitric Oxide donors and Arsenic Trioxide, known for inducing oxidative stress and DNA damage, respectively, further contribute to the potential activation of GADD45γ.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
An inhibitor of DNA topoisomerase I, known to induce DNA damage, potentially leading to the activation of GADD45γ as part of the DNA damage response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor that causes DNA damage and could stimulate the DNA damage response pathway, including the activation of GADD45γ. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A chemotherapy drug that induces DNA crosslinking, potentially activating GADD45γ as a response to DNA damage. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline antibiotic used in cancer therapy, known to induce DNA damage and potentially activate GADD45γ. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, leading to DNA replication stress, potentially activating GADD45γ. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog that disrupts DNA synthesis, potentially leading to GADD45γ activation as part of the DNA damage response. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Inhibits dihydrofolate reductase, leading to DNA synthesis disruption and potentially activating GADD45γ. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Induces DNA strand breaks, potentially activating GADD45γ as part of the DNA damage response pathway. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Known to induce cellular stress and DNA damage, potentially leading to the activation of GADD45γ. | ||||||