Molecular structure of 17-AAG, CAS Number: 75747-14-7
17-AAG (CAS 75747-14-7)
See product citations (16)
Alternate Names:
17-AAG is also known as Tanespimycin.
Application:
17-AAG is a potent heat shot protein 90 Hsp90) inhibitor for BT474 tumor cells, derived from geldanamycin.
CAS Number:
75747-14-7
Purity:
≥98%
Molecular Weight:
585.69
Molecular Formula:
C31H43N3O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
17-AAG, also known as Tanespimycin, is a benzoquinone ansamycin that has become a compound of interest in molecular chaperone research. It is known to inhibit Heat Shock Protein 90 (HSP90), a chaperone protein that plays a significant role in the folding, stability, and function of many client proteins, including those involved in signal transduction, cell cycle control, and survival. By binding to the ATP-binding domain of HSP90, 17-AAG disrupts its function, leading to the degradation of client proteins and the investigation of their cellular pathways. This property is particularly useful in the study of protein homeostasis and the cellular response to stress. In research environments, 17-AAG is employed to understand the mechanisms of action of HSP90 inhibitors and to explore the potential for targeting protein folding in various conditions. Furthermore, the compound is used to dissect the complex network of protein interactions that are critical for malignant transformation and to study the potential of HSP90 inhibitors in managing these processes.
17-AAG (CAS 75747-14-7) References
- 17-AAG: mechanisms of antitumour activity. | Konstantinopoulos, PA. and Papavassiliou, AG. 2005. Expert Opin Investig Drugs. 14: 1471-4. PMID: 16307487
- 17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines. | Babchia, N., et al. 2008. Invest Ophthalmol Vis Sci. 49: 2348-56. PMID: 18281615
- 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis. | Siegelin, MD., et al. 2009. Neurobiol Dis. 33: 243-9. PMID: 19027068
- Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. | Gaspar, N., et al. 2009. Cancer Res. 69: 1966-75. PMID: 19244114
- 17-AAG kills intracellular Leishmania amazonensis while reducing inflammatory responses in infected macrophages. | Petersen, AL., et al. 2012. PLoS One. 7: e49496. PMID: 23152914
- Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation. | Krishnamoorthy, GP., et al. 2013. J Biol Chem. 288: 17481-94. PMID: 23629654
- Effects of 17-AAG on the cell cycle and apoptosis of H446 cells and the associated mechanisms. | Zhao, X., et al. 2016. Mol Med Rep. 14: 1067-74. PMID: 27279418
- 17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells. | Zuo, Y., et al. 2020. Oncol Rep. 43: 1928-1944. PMID: 32236631
- A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells. | Hanna, R., et al. 2020. Front Oncol. 10: 624560. PMID: 33569349
- 17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death. | Petersen, ALOA., et al. 2021. Microorganisms. 9: PMID: 34069389
- Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats. | Marunouchi, T., et al. 2021. J Pharmacol Sci. 147: 192-199. PMID: 34384567
- HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages. | Zhang, S., et al. 2021. Front Cell Dev Biol. 9: 796974. PMID: 35059401
- The HSP90 inhibitor 17-AAG induced calcium-mediated apoptosis in filarial parasites. | Ahmad, F., et al. 2022. Drug Dev Res. 83: 1867-1878. PMID: 36219508
Inhibitor of:
α4-crystallin, β-defensin 137, β-defensin 15, β-defensin 32, β-defensin 7, βA4-crystallin, γ-crystallin, 14-3-3 θ, 4930539E08Rik, 6330534C20Rik, ACN9, AHSA2, Akt, ANKRD54, Ape2, APEH, Ataxin-3, Ataxin-8, ATXN7L2, AZI1, BAFL, Bag-2, Bag-3, Bag-5, BAG-6, BAT1, BBP, BC066028, BCAS2, BCLAF1, Bex4, BOLA1, BSDC1, BTBD14B, c-IAP 1, C14orf73, C17orf48, C19orf39, C19orf63, C1orf212, C1orf69, C20orf141, C20orf197, C230096C10Rik, C2orf47, C4orf52, C5orf27, C6orf120, Caper, CCDC147, CCDC55, CCDC56, CCT A, Cdc37, Cdc37L1, CEACAM18, chaperonin containing TCP1 ring complex (CCT), CLPX, CR16, Cre Recombinase, CYPOR, D630042P16Rik, DDA3, DDRGK1, DDX21, DDX24, DDX54, DEME-6, DHRS11, DKFZp667G2110, DNAAF3, DnaJB12, DnaJC16, DnaJC18, DnaJC25, Dok-1, Dynactin p135, EAF2, EF-1 α1, EG224763, EG225058, EG382275, EG436188, EG627009, EG627853, eIF5AL1, Ethanolamine kinase, FAIM, FAM115C, FAM12, FAM159A, FAM196B, FAM35A, FAM76A, FAM90A12, FAS-L, FBXW24, FKBP52, FLJ11184, FLJ13236, FNDC8, FNIP2, FOXK2, FOXO4, GADD 45γ, GAGE7, GM-CSFRα, Gm221, Gm6772, Gm884, GOLGA6L6, GRB7, GRIP1, GrpEL1, GrpEL2, GRWD1, GSDMC4, GTF2IRD2B, GTPBP4, hCG_1988300, HEATR8, Helicobacter pylori HSP, hnRNP E1, hnRNP J, HOM-TES-103, HPK1, HSBP1, HSBP1L1, HSF1, HSF2, HSF2BP, HSFX1, HSFY2, HSP 60, HSP 65, HSP 78, HSP 90, HSP 90α, HSPA12A, HSPA4L, HSPA6, HSPB3, HSPB7, HSPB9, HSPBAP1, HspBP1, HSPC016, HSPC117, HSPC159, HSPC196, Huntingtin, Hus1, I830012O16Rik, IBRDC1, Importin-9, Ini1, INTS7, IQCF5, IQCF6, ISG20L1, ISY1, K-Ras, Kar2, KIAA0040, KIAA0406, KIAA1107, kleisin β, KRI1, KRTAP4-5, KSHV ORF 45, L7RN6, LEKR1_Lekr1, LEMD1, LEMD2, LETM2, LOC100039282, LOC100040524, LOC100040885, LOC100041193, LOC100041226, LOC100041229, LOC100041389, LOC391359, LOC631145, LOC643909, LOC644366, LOC645307, LOC727844, LOC728241, LOC728414, LOC729363, LOC729417, LOXHD1, LRIG2, Ly-49T, M33, Membralin, Mex3b, MGC14376, MGC34761, MINK1, MLF1IP, Mlx, mPR, mPRε, Msn2, N-Ras, NAG7, NBK, NELIN, Ng23, NPIPL1, nucleoporin p62, Olfr607, Olfr608, Olfr609, Olfr61, ORP150, OS-9, OTTMUSG00000011097, P23, P2P-R, p68 RNA Helicase, PACT, Paip2, PAPD1, Paralemmin, PB1, PDCL2, PDILT, PERK, phostensin, PIH1D3, Pin1l, plexin-B3, Polyoma virus large T antigen, PPWD1, prefoldin 1, prefoldin 2, prefoldin 3, PTGES3L, PTGES3L-AARSD1, R3HDM1, R3HDM4, Rab 25, RAG-2, Ran, RAP80, RBM41, RBM46, Reprimo, REXO4, RGPD, Ribosomal Protein L35A-like, RNF38, RP24-329J6.2, RPIA, SAGE1, SBNO2, Sel-1L2, Ser/Thr Protein Kinase, SFRS11, SGT1, Smac, SMMHC, SorLA, SPATA5L1, SPEER-4D, SPEER-4E, SRCRB4D, SRm160, SRp55, SSH3, SSTK-IP, SUGT1, SUMF2, SUSD2, SVIP, SWI5, TCP-1 γ, TCP-1 θ, TCP-1 ζ2, TEL2, TERF1P2, THUMPD3, TID-1L, TIMP-1, TMEM191C, TPR, TRB-1, TRIM54, TSC-22 D4, TSCOT, TSPY, TTC17, TTC24, TTC34, TTC39C, UBE1Y1, UBE2E3, UBL4B, UBL5, Ubr7, UIP5, Ula1, UNC45A, URB2, USP17L7, USP17L8, UU12, UXT, VRK2, VWA9, WDR22, XAGE-1A, XAGE1E, XKR7, XKR9, Xlr3c, Xlr4c, Xlr5c, XTP13, Ydj1, YPEL2, ZC3HAV1L, ZCCHC2, ZFAND2A, Zfp874, Zhangfei, ZKSCAN4, ZNF16, ZNF248, ZNF512, ZNF662, ZNF696, ZNF7, ZNF707, ZNF71, ZNF726, ZNF774, ZNF844, and ZNF852.Activator of:
α3d Tubulin, α4-crystallin, γC-crystallin, 1500002O20Rik, 1700003F12Rik, 4E-BP2, ABCC11, ACF, AGR2, AKR1B7, ANKRD9, APIP, ASB-11, ASB-13, ASB-17, Ataxin-1, ATBF1, ATXN3L, B7-H6, BAP29, BC015286, BCAS3, BLOS2, BNIP-1, C10orf6, C1orf151-NBL1, C6orf113, CCDC169-SOHLH2, CCT B, Cdc37L1, CESK1, CHIP, CHMP4, CLCC1, COP1, CSP, CT47A12, Cyp60, D630042P16Rik, Dab2, Dbp5, DDX43, DDX50, DDX57, DEK, DIS3L2, DNA Ligase III, DnaJA2, DnaJA4, DnaJB6, DnaJC1, DnaJC11, DnaJC7, DnaJC9, DNAL4, DYNC2LI1, EG637776, eIF5A2, Exportin 4, FBXO11, FBXO18, FBXO33, Fbxw21, FKBP10, FKBP11, FKBP52, FKBP9, FKBPL, FLJ44635, FRG2B, FSD1, GOLPH4, GOLT1A, GP78-1, GP78-2, Gpr165, GrpEL1, Herc2, HIP1, Hrnbp3, HRSP12, HSF3, HSF5, HSFY1, HSP 10, HSP 20, HSP 27, HSP 40, HSP 40-4, HSP 47, HSP 70, HSP 75, HSP 78, HSP 90, Hsp70-3, HSPA12B, HSPA1L, HSPA2, HSPA4L, HSPB11, HSPB2, HSPC121, HSPC171, HSPE1-MOB4, HTPAP, HYPK, INO80C, ISY1, ITM1, JKTBP, KBTBD5, KLHDC9, KLHL4, KRTAP9-L2, LBA1, LOC440233, LOC727873, LOC728373, LSP1, MAGE-B3, Makorin-2, MARCH6, MCT4, MESDC2, Mex67, MMGT1, Mnt, Morc3, MRGX2, MSANTD3-TMEFF1, NBPF10, Nibrin, NPIPL1, Nrdp1, NT-4, NVL, OIP106, oogenesin 2, oogenesin 3, oogenesin 4, PABPC5, PARC, PDDC1, PGBD1, PIG-S, POP1, PPIAL4, PPIAL4C, PPIAL4D, PPIAL4F, PPIL2, prefoldin 4, PTIP, PTTG, Ran GAP1, RBM4B, Rer1, RNF103-CHMP3, RNF13, RNF148, RNF165, RNF180, RNF212, RNF25, RNF26, RNF40, RPAP1, RPL10L, Rpn2, se57-1, SEC11A, Sec63, Sel-1L3, SFRS2IP, SGTA, SGTB, SIAH3, SIL1, SMC4, SNX1A, SNX31, SPC12, SRP54, SRP72, Ssa1, Ssa2, STCH, STI1, StIP1, STOX1, SUG1, Swe1, syncytin-B, TCP-1 α, TCP-1 β, TCP-1 ζ, TEX14, TEX264, TFIIH p34, THAP9, THOC2, TID-1, TMEM111, TMEM160, TMEM92, TRAM1L1, TRAP1, Trap1a, TRIM50, TRIM58, TRIM60, TSEN2, TTC4, TudorSN, TXNDC15, UBA3, UBE2A, UBE2C, UBL7, UBXD3, UCH-L5, Ufc1, UFD1, UNCL, USP45, VPS13D, WAPL, WDR41, Wig-1, WSCD2, YIPF1, ZCCHC8, ZCSL3, ZFAND1, ZMYM6NB, ZNF300, ZNF589, ZNF598, ZNF618, ZNF670, and Zuotin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-AAG, 1 mg | sc-200641 | 1 mg | $67.00 | |||
17-AAG, 5 mg | sc-200641A | 5 mg | $156.00 |