GADD 45α Activators
Common GADD 45α Activators include, but are not limited to Arsenic(III) oxide CAS 1327-53-3, Temozolomide CAS 85622-93-1, 5-Aza-2′-Deoxycytidine CAS 2353-33-5, Trichostatin A CAS 58880-19-6 and D,L-Sulforaphane CAS 4478-93-7.
GADD 45α (Growth Arrest and DNA Damage-inducible protein 45 alpha) is a member of the GADD45 family of proteins that serve as crucial sentinels in maintaining cellular integrity. As its name suggests, GADD 45α is swiftly induced in response to various forms of cellular stress, particularly DNA damage. The protein plays a pivotal role in a plethora of cellular processes, such as cell cycle arrest, DNA repair, apoptosis, and cellular senescence. Functioning at the crossroads of these processes, GADD 45α is essential for ensuring that cells respond aptly to damage and maintain genomic stability. It achieves its multifaceted roles through interactions with a range of other proteins, including p21, Cdc2, and PCNA, allowing it to modulate the cell cycle and DNA repair machinery. The precise orchestration of GADD 45α activity is, therefore, paramount for cellular survival, especially under conditions of genotoxic stress.
Activators of GADD 45α are molecules or compounds that augment the expression, stability, or activity of GADD 45α. These activators might function by enhancing the transcription or translation of the GADD 45α gene, bolstering the protein's stability, or facilitating its interaction with other cellular partners. The presence of GADD 45α activators can profoundly influence the dynamics of cellular stress responses, amplifying processes like DNA repair, cell cycle checkpoints, or programmed cell death. Delving into the world of GADD 45α activators provides a deep understanding of the nuanced regulation of cellular responses to genotoxic insults. As the elaborate choreography of cellular stress responses continues to be explored, the role of GADD 45α and its activators emerges as a central narrative, illuminating the molecular mechanisms that guide cell fate decisions in the face of adversity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces GADD45α expression and promotes cell cycle arrest and apoptosis, especially in malignant cells. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $91.00 $255.00 | 32 | |
An alkylating agent that can induce DNA damage, leading to the upregulation of GADD45α and subsequent cell cycle arrest and apoptosis. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methylation inhibitor which can upregulate GADD45α expression, leading to cell cycle arrest. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that can increase the expression of GADD45α, leading to enhanced DNA repair and cell cycle arrest. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
A compound found in cruciferous vegetables that can induce GADD45α expression, promoting DNA repair and cell cycle arrest. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A polyphenolic compound that can upregulate GADD45α, leading to enhanced DNA repair and apoptosis in cancer cells. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that can induce GADD45α expression, enhancing DNA repair mechanisms and promoting apoptosis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Induces GADD45α expression, potentially through its antioxidant properties, leading to DNA repair and cell cycle arrest. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor that can cause DNA damage, leading to the upregulation of GADD45α and subsequent cell cycle arrest and apoptosis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that can induce GADD45α expression, leading to enhanced DNA repair mechanisms and apoptosis. | ||||||