GADD 34 Inhibitors
Common GADD 34 Inhibitors include, but are not limited to Salubrinal CAS 405060-95-9, Thapsigargin CAS 67526-95-8, Guanfacine CAS 29110-47-2, GSK PERK Inhibitor CAS 1337531-89-1 and TC-E 5003 CAS 17328-16-4.
GADD34 inhibitors belong to a chemical class of compounds designed to modulate the activity of Growth Arrest and DNA Damage-Inducible Protein 34 (GADD34). GADD34, also known as PPP1R15A, is a regulatory protein involved in cellular stress responses, particularly in the context of cellular growth arrest and DNA damage. GADD34 plays a crucial role in the integrated stress response pathway, which helps cells adapt to various stressors, such as endoplasmic reticulum (ER) stress and nutrient deprivation.
Inhibitors in the GADD34 class are developed to interfere with the function of GADD34, affecting its interactions with other cellular components and altering downstream signaling cascades. By modulating GADD34 activity, these inhibitors impact stress response pathways, cellular growth regulation, and DNA damage repair mechanisms. The study of GADD34 inhibitors contributes to a better understanding of the intricate regulatory networks that govern cellular stress responses, offering insights into how cells cope with adverse conditions and maintain their functional integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $241.00 | ||
Inhibits GADD34 by promoting its interaction with eIF2α, preventing eIF2α dephosphorylation and maintaining translation repression. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Prevents GADD34 from associating with PP1, leading to sustained phosphorylation of eIF2α and continued translation repression. | ||||||
Sephin1 | 13098-73-2 | sc-507502 | 5 mg | $578.00 | ||
Blocks the interaction between GADD34 and eIF2α, inhibiting eIF2α dephosphorylation and helping to maintain protein synthesis arrest. | ||||||
Guanfacine | 29110-47-2 | sc-353618 | 200 mg | $1900.00 | ||
Similar to guanabenz, guanfacine inhibits GADD34's interaction with eIF2α, thereby preventing translation recovery after stress. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
Acts downstream of GADD34 by inhibiting eIF2B, enhancing the translation recovery process despite eIF2α phosphorylation. | ||||||
BGP-15 | 66611-37-8 | sc-507452 | 10 mg | $375.00 | ||
Interferes with GADD34-PP1 interaction, resulting in sustained eIF2α phosphorylation and prolongation of translation repression. | ||||||
GSK PERK Inhibitor Inhibitor | 1337531-89-1 | sc-490139 | 1 mg | $300.00 | ||
Inhibits PERK, one of the kinases activating GADD34, reducing its function in the recovery of translation after stress. | ||||||
TC-E 5003 | 17328-16-4 | sc-397056 | 50 mg | $148.00 | 3 | |
Blocks eIF4A activity, leading to the suppression of translation initiation and potentially impacting GADD34-mediated functions. | ||||||
2-Aminopurine | 452-06-2 | sc-287828 sc-287828A | 100 mg 250 mg | $118.00 $185.00 | ||
Inhibits eIF2α kinases, reducing eIF2α phosphorylation and affecting GADD34-mediated translation recovery following stress. | ||||||