Molecular structure of Guanfacine, CAS Number: 29110-47-2
Guanfacine (CAS 29110-47-2)
Alternate Names:
N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
CAS Number:
29110-47-2
Molecular Weight:
246.09
Molecular Formula:
C9H9Cl2N3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanfacine is an activator of α2A-AR.
Guanfacine (CAS 29110-47-2) References
- The effects of guanfacine, alpha-2 agonist, on the performance of young and aged rats in spatial navigation task. | Sirviö, J., et al. 1991. Behav Neural Biol. 56: 101-7. PMID: 1651076
- Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats. | Lê, AD., et al. 2011. Psychopharmacology (Berl). 218: 89-99. PMID: 21318567
- Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist. | Li, X., et al. 2015. Xenobiotica. 45: 88-94. PMID: 25115365
- Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits. | Shimizu, S., et al. 2015. Auton Neurosci. 187: 84-7. PMID: 25498385
- Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice. | Mineur, YS., et al. 2015. Psychopharmacology (Berl). 232: 3539-49. PMID: 26146014
- A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity. | Dudek, M., et al. 2015. PLoS One. 10: e0141327. PMID: 26506439
- Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation. | Kawada, T., et al. 2016. Life Sci. 149: 72-8. PMID: 26883977
- Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior. | Freund, N., et al. 2019. Psychopharmacology (Berl). 236: 685-698. PMID: 30411140
- The use of reaction time distributions to study attention in male rats: the effects of atomoxetine and guanfacine. | Redding, ZV., et al. 2019. Psychopharmacology (Berl). 236: 3579-3592. PMID: 31321458
- Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model. | Lukkes, JL., et al. 2020. J Neurodev Disord. 12: 2. PMID: 31941438
- Effects of the α-2 Adrenergic Receptor Agonists Lofexidine and Guanfacine on Food-Cocaine Choice in Socially Housed Cynomolgus Monkeys. | Czoty, PW. and Nader, MA. 2020. J Pharmacol Exp Ther. 375: 193-201. PMID: 32636208
- Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration. | Wagener, N., et al. 2022. Int J Mol Sci. 23: PMID: 36142172
- The effects of clonidine, guanfacine and phenylephrine on the excitatory and inhibitory responses of the rat anococcygeus muscle. | Uzbay, IT. and Onur, R. 1993. Arch Int Physiol Biochim Biophys. 101: 361-5. PMID: 7511429
Inhibitor of:
Dexras2, eIF2Bα, eIF2C3, GADD 34, Olfr773, Olr1413, Olr1595, P-Selectin, Slc6a16, and Torsin3A.Activator of:
α2C-AR, 1700039E15Rik, alpha2A-AR, NETO1, SLC17A2, Syntaxin 1, and VGAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanfacine, 200 mg | sc-353618 | 200 mg | $1900.00 |