GADD 34 Activators

Common GADD 34 Activators include, but are not limited to Thapsigargin CAS 67526-95-8, Tunicamycin CAS 11089-65-9, DTT CAS 27565-41-9, Brefeldin A CAS 20350-15-6 and Hydrogen Peroxide CAS 7722-84-1.

GADD34 (Growth Arrest and DNA Damage-Inducible Protein 34) is a cellular protein involved in the integrated stress response (ISR), a mechanism activated in response to various cellular stressors such as DNA damage, nutrient deprivation, or endoplasmic reticulum (ER) stress. GADD34 plays a crucial role in regulating the ISR by forming a complex with protein phosphatase 1 (PP1) to dephosphorylate eukaryotic initiation factor 2 alpha (eIF2α). This dephosphorylation event restores the activity of eIF2α and allows for the resumption of protein synthesis, which is often inhibited during stress to conserve cellular resources. Therefore, GADD34 activators are compounds or molecules that enhance the activity or function of GADD34, ultimately influencing the cellular response to stress.

GADD34 activators typically work by either stabilizing the GADD34 protein or promoting its interaction with its binding partner, PP1. This interaction is pivotal because it leads to the dephosphorylation of eIF2α, which, in turn, regulates protein synthesis. By studying GADD34 activators, researchers can gain insights into the molecular mechanisms governing the ISR and its role in cellular stress responses. Understanding how GADD34 is regulated and activated is essential in deciphering the intricate network of stress responses in cells, which has implications for various physiological and pathological conditions. GADD34 activators serve as valuable tools in the laboratory, aiding scientists in elucidating the functions and signaling pathways associated with this important stress response protein.