Tunicamycin CAS: 11089-65-9
MF: C38H62N4O16 (Tun B)
MW: 840.0 (Avg.)

Tunicamycin (CAS 11089-65-9)

Tunicamycin | CAS 11089-65-9 is rated 4.5 out of 5 by 2.
  • y_2021, m_5, d_15, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.15
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3506, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 7ms
  • REVIEWS, PRODUCT
5
1
4
1
3
0
2
0
1
0
Alternate Names: Tunicamycin also known as nucleoside antibiotic
Application: Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties and is widely used in the study of glycoprotein synthesis
CAS Number: 11089-65-9
Purity: ≥99% (total complex)
Molecular Weight: 840.0 (Avg.)
Molecular Formula: C38H62N4O16 (Tun B)
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tunicamycin is a mixture of tunicamycins A, B, C and D and has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GlcNAc phosphotransferase (GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein sunthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, inhibit protein glycosylation, suppression of the S phase and to also arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, tunicamycin is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Through this mechanism, it has been postulated to arrest cell cycling as a competitive inhibitor of glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins which thereby affect the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.


References

1. Duksin, D., et al. 1982. J. Biol. Chem. 257: 3105-3109. PMID: 7061468

2. Langan, T.J. and Slater, M.C. 1991. J. Cell Physiol. 149: 284-292. PMID: 1748720

3: Ishii, S. and Volpe, J.J. 1987. J. Neurochem 49: 1606-1612. PMID: 3668542

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water.
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YO7980200
Merck Index :
14: 9819
MDL Number :
MFCD00065709
Beilstein Registry :
6888090

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Tunicamycin (CAS 11089-65-9)  Product Citations

See how others have used Tunicamycin (CAS 11089-65-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 45 total

PMID: # 31381163  2019. Hepatology.

PMID: # 30100737  Chen, J. et al. 2018. Onco Targets Ther. 11: 4315-4325.

PMID: # 28953979  English, BC. et al. 2017. PLoS Pathog. 13: e1006589.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 29118074  Baumann, J. et al. 2017. Mol. Biol. Cell.

PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 25903460  Kim, AY. et al. 2015. BMC Genomics. 16: 338.

PMID: # 26040720  Khaminets, A. et al. 2015. Nature. 522: 354-8.

PMID: # 25824232  Li, R. et al. 2015. Antimicrob. Agents Chemother. 59: 3460-8.

Citations 1 to 10 of 45 total

Why is tunicamycin insoluble in water?

Asked by: rachel220
Thank you for your question. This biochemical is soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service
Date published: 2019-03-25

What is a differences between Tunicamycin A, B,C,D?

Asked by: r7r sh
Thank you for the question. Tunicamycin is not a single compound but a mixture of homologous antibiotics. Our product was derived from Streptomyces sp. and it contains a mixture of Tunicamycin A, B,C and D. Tunicamycin A, B,C,D are homologs varying in the length of the carbon chain: Tunicamycin A = 8C, Tunicamycin B = 9C, Tunicamycin C = 10C and Tunicamycin D = 11C.
Answered by: Technical Support Europe
Date published: 2017-12-03

How should this be stored once dissolved in DMSO?

Asked by: SCM4
Because we do not have storage information once dissolved in DMSO, we do not recommending storing this product in DMSO. However, typically for long term storage in DMSO, other compounds are aliquoted and stored at -20 ºC to -80 ºC for 3-4 months in order to avoid repeated freeze/thaw cycles.
Answered by: Tech Service 11
Date published: 2017-03-17
  • y_2021, m_5, d_15, h_18CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.15
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_3
  • loc_en_US, sid_3506, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 16ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Good product This chemical works well in primary neuronal culture system
Date published: 2018-10-03
Rated 5 out of 5 by from Ren et Ren et. al. (PubMed ID 19276076) used tunimycin to initiate endoplasmic reticulum stress. -SCBT Publication Review
Date published: 2015-04-13
  • y_2021, m_5, d_15, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.15
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3506, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.