Molecular structure of Sephin1, CAS Number: 13098-73-2
Sephin1 (CAS 13098-73-2)
Alternate Names:
Sephin-1 Sephin 1
CAS Number:
13098-73-2
Molecular Weight:
196.64
Molecular Formula:
C8H9ClN4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Sephin1 (CAS 13098-73-2) References
- A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α. | Crespillo-Casado, A., et al. 2018. J Biol Chem. 293: 7766-7776. PMID: 29618508
- Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. | Chen, Y., et al. 2019. Brain. 142: 344-361. PMID: 30657878
- Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections. | Fusade-Boyer, M., et al. 2019. Front Immunol. 10: 134. PMID: 30809223
- Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. | Thapa, S., et al. 2020. Mol Neurobiol. 57: 2206-2219. PMID: 31981074
- Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response. | Ruiz, A., et al. 2020. Int J Mol Sci. 21: PMID: 32846985
- Guanabenz ameliorates disease in vanishing white matter mice in contrast to sephin1. | Witkamp, D., et al. 2022. Ann Clin Transl Neurol. 9: 1147-1162. PMID: 35778832
- Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity. | Wang, R., et al. 2023. iScience. 26: 105954. PMID: 36718369
- Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response. | Chen, Y., et al. 2023. Glia. 71: 2180-2195. PMID: 37203250
- Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis. | Ding, ZB., et al. 2024. Acta Pharmacol Sin. 45: 790-802. PMID: 38191913
- Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice. | Wu, Y., et al. 2024. Biomed Pharmacother. 176: 116869. PMID: 38850665
Inhibitor of:
(eukaryotic translation initiation factor) eIF, (eukaryotic translation initiation factor) eIF1, (eukaryotic translation initiation factor) eIF2, (eukaryotic translation initiation factor) eIF5, ATF-6, CCDC47, eIF2α, GADD 34, GLT8D2, HRI, KDEL receptor 2, KIAA0141, Membralin, MGC29506, P-Selectin, PERK, PPP1R15B, PPP1R3G, RECS1, TIA-1, TMCO4, and TMTC4.Activator of:
eIF2Bα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sephin1, 5 mg | sc-507502 | 5 mg | $578.00 |