P-Selectin Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $241.00 | ||
Inhibits GADD34 by promoting its interaction with eIF2α, preventing eIF2α dephosphorylation and maintaining translation repression. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Prevents GADD34 from associating with PP1, leading to sustained phosphorylation of eIF2α and continued translation repression. | ||||||
Sephin1 | 13098-73-2 | sc-507502 | 5 mg | $578.00 | ||
Blocks the interaction between GADD34 and eIF2α, inhibiting eIF2α dephosphorylation and helping to maintain protein synthesis arrest. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Induces ER stress and inhibits the GADD34-PP1 interaction, prolonging eIF2α phosphorylation and translation repression. | ||||||
Guanfacine | 29110-47-2 | sc-353618 | 200 mg | $1900.00 | ||
Similar to guanabenz, guanfacine inhibits GADD34's interaction with eIF2α, thereby preventing translation recovery after stress. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
Acts downstream of GADD34 by inhibiting eIF2B, enhancing the translation recovery process despite eIF2α phosphorylation. | ||||||
BGP-15 | 66611-37-8 | sc-507452 | 10 mg | $375.00 | ||
Interferes with GADD34-PP1 interaction, resulting in sustained eIF2α phosphorylation and prolongation of translation repression. | ||||||
GSK 2606414 | 1337531-36-8 | sc-490182 sc-490182A | 5 mg 25 mg | $160.00 $561.00 | ||
Inhibits PERK, one of the kinases activating GADD34, reducing its function in the recovery of translation after stress. | ||||||
TC-E 5003 | 17328-16-4 | sc-397056 | 50 mg | $148.00 | 3 | |
Blocks eIF4A activity, leading to the suppression of translation initiation and potentially impacting GADD34-mediated functions. | ||||||
2-Aminopurine | 452-06-2 | sc-287828 sc-287828A | 100 mg 250 mg | $118.00 $185.00 | ||
Inhibits eIF2α kinases, reducing eIF2α phosphorylation and affecting GADD34-mediated translation recovery following stress. | ||||||