Molecular structure of TC-E 5003, CAS Number: 17328-16-4
TC-E 5003 (CAS 17328-16-4)
See product citations (3)
Alternate Names:
N,N′-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Application:
TC-E 5003 is a selective PRMT1 inhibitor
CAS Number:
17328-16-4
Molecular Weight:
401.26
Molecular Formula:
C16H14Cl2N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TC-E 5003 is a biochemical compound. It is involved in the regulation of certain cellular processes, particularly those related to gene expression and protein synthesis. TC-E 5003 interacts with specific enzymes and signaling molecules within the cell, affecting their activity and ultimately influencing the function of the cell. TC-E 500 plays a role in the modulation of various metabolic pathways, contributing to the maintenance of cellular homeostasis. TC-E 5003 is an important chemical in biochemistry, providing insights into the fundamental processes that govern life at the molecular level.
TC-E 5003 (CAS 17328-16-4) References
- PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model. | Bayen, S., et al. 2018. Endocrine. 59: 151-163. PMID: 29128891
- Protein arginine methyltransferase expression and activity during myogenesis. | Shen, NY., et al. 2018. Biosci Rep. 38: PMID: 29208765
- PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia. | He, X., et al. 2019. Blood. 134: 548-560. PMID: 31217189
- Developing protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems. | Zhang, P., et al. 2020. Drug Deliv. 27: 491-501. PMID: 32212935
- Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. | Kim, E., et al. 2020. Int J Mol Sci. 21: PMID: 32357521
- TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes. | Park, MJ., et al. 2020. FEBS Lett. 594: 2923-2930. PMID: 32767856
- DNA or Protein Methylation-Dependent Regulation of Activator Protein-1 Function. | Kim, E., et al. 2021. Cells. 10: PMID: 33670008
- The Role of AP-1 Transcription Factors in Plasma Cell Biology and Multiple Myeloma Pathophysiology. | Fan, F. and Podar, K. 2021. Cancers (Basel). 13: PMID: 34066181
- Epigenetic Crosstalk between Malignant Plasma Cells and the Tumour Microenvironment in Multiple Myeloma. | Allegra, A., et al. 2022. Cancers (Basel). 14: PMID: 35681577
- Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ. | Zhu, Q., et al. 2022. J Biol Chem. 298: 102309. PMID: 35921899
- The role of protein arginine N-methyltransferases in inflammation. | Chen, T., et al. 2022. Semin Cell Dev Biol.. PMID: 36075843
- Resveratrol improves diabetic cardiomyopathy by preventing asymmetric dimethylarginine-caused peroxisome proliferator-activated receptor-γ coactivator-1α acetylation. | Fang, WJ., et al. 2022. Eur J Pharmacol. 936: 175342. PMID: 36341883
- Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro. | Li, ASM., et al. 2023. Biochim Biophys Acta Gene Regul Mech. 1866: 194922. PMID: 36822575
- CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. | Yin, S., et al. 2023. Cell Rep. 42: 112316. PMID: 36995937
- PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation. | Zhang, L., et al. 2023. Cell Death Dis. 14: 233. PMID: 37005412
Inhibitor of:
ATP6F, BMS1, CCP6, GADD 34, JMJD1B, P-Selectin, PDE2A, PRA1, PRMT1, PRMT10, and UTX.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TC-E 5003, 50 mg | sc-397056 | 50 mg | $151.00 |