Molecular structure of Salubrinal, CAS Number: 405060-95-9
Salubrinal (CAS 405060-95-9)
See product citations (87)
Alternate Names:
Salubrinal is known as an eIF-2α inhibitor.
Application:
Salubrinal is a cell permeable and selective inhibitor of eIF-2α used to study ER stress-induced apoptosis.
CAS Number:
405060-95-9
Purity:
≥98%
Molecular Weight:
479.81
Molecular Formula:
C21H17Cl3N4OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Salubrinal is a cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50~15μM) in PC12 cell lines induced with the protein glycosylation inhibitor tunicamycin (sc-201539), and brefeldin A (sc-200861), which causes ER stress by blocking ER-to-Golgi vesicle transport. Salubrinal is a potentially useful agent to study mechanisms of ER stress-induced apoptosis.
Salubrinal (CAS 405060-95-9) References
- A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. | Boyce, M., et al. 2005. Science. 307: 935-9. PMID: 15705855
- A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. | Boyce, M., et al. 2008. Cell Death Differ. 15: 589-99. PMID: 18188169
- Early endosomes and endosomal coatomer are required for autophagy. | Razi, M., et al. 2009. J Cell Biol. 185: 305-21. PMID: 19364919
- Salubrinal attenuated retinal neovascularization by inhibiting CHOP-HIF1α-VEGF pathways. | Hu, Y., et al. 2017. Oncotarget. 8: 77219-77232. PMID: 29100382
- Roles of endoplasmic reticulum stress and autophagy on H2O2‑induced oxidative stress injury in HepG2 cells. | Wu, Z., et al. 2018. Mol Med Rep. 18: 4163-4174. PMID: 30221706
- Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress. | Li, W., et al. 2020. DNA Cell Biol. 39: 210-225. PMID: 31809190
- Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis. | Wang, Z., et al. 2021. Int J Mol Sci. 22: PMID: 33800699
- Salubrinal Exposes Anticancer Properties in Inflammatory Breast Cancer Cells by Manipulating the Endoplasmic Reticulum Stress Pathway. | Alsterda, A., et al. 2021. Front Oncol. 11: 654940. PMID: 34094947
- Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress. | Chen, MC., et al. 2021. Biomedicines. 9: PMID: 34572286
- Salubrinal protects against inflammatory response in macrophage and attenuates psoriasiform skin inflammation by antagonizing NF-κB signaling pathway. | Shangguan, Y., et al. 2022. Biochem Biophys Res Commun. 589: 63-70. PMID: 34891043
- The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats. | Cankara, FN., et al. 2022. Immunopharmacol Immunotoxicol. 44: 168-177. PMID: 35021949
- Salubrinal-mediated activation of eIF2α signaling improves oxidative stress-induced BMSCs senescence and senile osteoporosis. | Li, L., et al. 2022. Biochem Biophys Res Commun. 610: 70-76. PMID: 35439699
- Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice. | Lopez, NH., et al. 2022. PLoS One. 17: e0261799. PMID: 35639781
- Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling. | Lu, W., et al. 2022. Front Mol Neurosci. 15: 916458. PMID: 35706425
Inhibitor of:
(eukaryotic translation initiation factor) eIF, (eukaryotic translation initiation factor) eIF1, (eukaryotic translation initiation factor) eIF4, (eukaryotic translation initiation factor) eIF5, 3110043O21Rik, 4930511M11Rik, 9030025P20Rik, A530082C11Rik, AGR2, Apoptosis, ARL6IP4, Ataxin-7, ATF-3, ATF-6, ATF-6β, atrophin-1, BAG-6, BAP29, BNIP-1, C/EBP β, C19orf63, C1GALT1, Calumenin, CCDC47, Cdc14b Phosphatase, CHAC2, CPN reg, CREB3L1, CREB3L2, CRELD2, DDRGK1, DnaJC5γ, DPM1, eIF1AY, eIF2α, eIF2Bα, eIF2Bδ, eIF2C3, eIF3M, eIF4B, eIF5A1, eRF1, Ero1-Lα, FAM134A_Fam134a, Fukutin, GADD 153, GADD 34, GCN1L1, GCN2, Glrp-1, GLT8D2, Glycogenin (GYG), GOLGA8A, HRI, HSFX1, Huntingtin, JWA, KBTBD3, KCTD19, KDEL ER Marker, KDEL receptor 2, KIAA0141, KIAA0406, Kinectin 1, KLHDC7A, KLHL35, LOC100041076, LOC728861, Membralin, MGC29506, MKP-3, MR1, NP220, Olfr481, ORP150, OSTM1, P-Selectin, PDILT, PDIR, PERK, PHLPPL, phosphatasefamily surface anchored protein, PHPT1, PP1γ, PPP1R15B, PPP1R3, PPP1R3G, Ppp4r1l, PRH2, PRIP, PRPK, PSM, Psmg2, PSTPIP2, PTP beta, PTPN21, PTPRCAP, Puratrophin 1, Ramp4, Ramp4-2, Rb, RECS1, REEP5, reticulocalbin-1, Reticulum Cell, Ribophorin I, Ribophorin II, scotin, SDF-2L1, SDF-4, Sec13, SEC22A, Sec62, SLC35A3, Sp5, SURF-4, Synoviolin, Thomsen-Friedenreich, TIA-1, TMCO4, TMED9, TMTC4, Torsin4A, TRAM2, TRAP-β, TRS85, TXNDC10, Type I 4-phoshatase β, Type II 4-phoshatase, Type II 4-phoshatase β, UBL4A, Ubr2, VAP-A, WDPCP, XTP3-B, YIPF1, YIPF3, and Zhangfei.Activator of:
β-TrCP, 26S Proteasome p58, AGR2, APG7, ARMER, Ataxin-3, ATF-5, ATF-6, ATF-6α, Atlastin-3, Bag-2, Bag-5, BAP29, Bet1L, Bex6, BRAT1, BZW1, Calnexin, CALR4, CDNF, CHCHD1, CLN8, CREB-2, CREB3L4, CSP, DCHS1, Derlin-2, DJ-1, DnaJB12, DnaJC1, DnaJC10, DnaJC9, DPAGT1, DR5, EG435337, eIF2A, eIF2Bε, eIF2Bγ, eIF2D, eIF2S3, eIF3 p110, eIF3θ, EPC1, ERGIC-3, ERp27, EVA1B, FAM62C, FBXO2, FDXACB1, G3BP1, GLT8D4, Glucosidase IIα, GrpEL1, HERPUD2, HGTD-P, HisRS, HRI, HSPA14, HSPA4L, HYPK, ITM1, KBTBD5, KCMF1, KDEL receptor, LARS2, LIX1L, LOC392288, LONRF3, Lunapark, Maestro, MAN1A2, MCFD2, MECL-1, Mnk1, NVL, OAS1, Pax-7, Pecanex 2, PP2A-γ, prefoldin 3, prefoldin 4, PRR20B, PSMD12, PTAG, RAIDD, RBM4, Rer1, RHBDL2, RNF13, RNF148, RNF220, RPAP1, RPLL26L1, RRBP1, SCRG1, SEC11A, Sec31A, Sec61α1, Sec61γ, Sec63, Sel-1L, SERF1, SGTA, SGTB, SIL1, SIRT2, SP-C, SPC12, SQSTM1-L1, SRP72, Tau, TCP-1 α, TCP-1 θ, TCP-1 ζ2, TEX264, TID-1, TMEM156, TMEM39A, TMX3, TRIM58, TRIM6-TRIM34, TSR3, TXNDC1, TYW3, Ufc1, UFD1, UFSP1, UIP5, USP45, WIPI-1, Wolframin, XBP-1, YIPF1, ZC3H11A, ZNF598, and Zuotin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Salubrinal, 1 mg | sc-202332 | 1 mg | $33.00 | |||
Salubrinal, 5 mg | sc-202332A | 5 mg | $102.00 |