GSK PERK Inhibitor Inhibitor (CAS 1337531-89-1)
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The GSK PERK inhibitor stands as a remarkable small molecule compound designed to target the protein kinase RNA-like endoplasmic reticulum kinase (PERK). PERK assumes a pivotal role as a regulator within the unfolded protein response (UPR) pathway, which holds paramount importance in maintaining cellular homeostasis. Activation of the UPR pathway occurs in response to endoplasmic reticulum (ER) stress, provoked by the accumulation of misfolded proteins within the ER. Upon activation, the UPR pathway orchestrates the reduction of protein synthesis and the upregulation of genes involved in protein folding and degradation. The proposed mechanism of action revolves around inhibiting GSK PERK-mediated phosphorylation of eIF2α, which subsequently curtails protein synthesis while augmenting the expression of genes involved in protein folding and degradation.
GSK PERK Inhibitor Inhibitor (CAS 1337531-89-1) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK PERK Inhibitor, 1 mg | sc-490139 | 1 mg | $300.00 |