FOXA3 Inhibitors
FOXA3 inhibitors are a class of chemical compounds designed to modulate the activity of the transcription factor FOXA3 (Forkhead Box A3). FOXA3 belongs to the Forkhead family of transcription factors, which are characterized by a conserved winged-helix DNA-binding domain. As a transcription factor, FOXA3 plays a critical role in regulating the expression of genes involved in various biological processes, including metabolism, cellular differentiation, and tissue development. Inhibitors of FOXA3 aim to reduce or block its ability to bind to DNA and initiate transcription, which can lead to alterations in the expression of target genes under its regulatory control. The mechanism by which FOXA3 inhibitors exert their effects typically involves direct binding to the transcription factor itself or interference with its interaction with cofactors or DNA.
Structurally, FOXA3 inhibitors can vary significantly, depending on their mode of action and specificity. Some may resemble small molecules that compete with DNA for FOXA3 binding, while others could target allosteric sites to induce conformational changes that inhibit the factor's activity. The diversity in their chemical structure is often related to the specific aspects of FOXA3 function they aim to disrupt, such as DNA-binding affinity, protein stability, or nuclear localization. These inhibitors may be developed through various screening techniques, including high-throughput chemical libraries or rational drug design based on the crystal structure of FOXA3. By modulating the activity of this transcription factor, researchers can investigate its role in regulating various cellular pathways, which contributes to a better understanding of FOXA3's functional relevance in cell biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate FOXA3 by enhancing acetylation of histones at the promoter region, thereby disrupting the assembly of transcriptional machinery required for FOXA3 gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could decrease FOXA3 levels by incorporating into DNA and RNA, leading to the inhibition of DNA methyltransferases, which results in hypomethylation of the FOXA3 promoter, hampering its transcriptional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid may reduce the transcriptional efficiency of FOXA3 by altering the differentiation status of cells, particularly in tissues where FOXA3 plays a developmental role, thereby changing the transcriptional dynamics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has the potential to decrease FOXA3 expression through the suppression of NF-κB pathway activation, leading to reduced transcription of FOXA3 due to lower promoter activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could downregulate FOXA3 expression by enhancing the deacetylation activity of sirtuins on histones associated with the FOXA3 gene, leading to tighter chromatin and less access for transcription factors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane might decrease FOXA3 transcription by activating Nrf2, which could shift the cellular oxidative state and indirectly lead to a reduction in the transcriptional activity of the FOXA3 gene. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin may inhibit FOXA3 expression by activating AMPK, which can suppress mTOR signaling, consequently leading to a reduction in protein synthesis machinery, including that for FOXA3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could downregulate FOXA3 by inhibiting the activity of DNA methyltransferases and histone acetyltransferases, leading to epigenetic modifications that result in the silencing of the FOXA3 gene. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone might reduce FOXA3 expression by acting as a PPARγ agonist, leading to the activation of genes involved in lipid metabolism and adipocyte differentiation, which could suppress FOXA3 expression through negative feedback mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could inhibit the transcription of FOXA3 by stabilizing cellular antioxidant defenses, leading to the attenuation of oxidative stress-related signaling pathways that would otherwise enhance FOXA3 expression. | ||||||