FIR Activators
FIR Activators, a diverse group of chemical compounds, are specifically tailored to enhance the activity of the Functionally Interacting Region (FIR) within certain proteins. These activators are distinct in their mechanisms, targeting the intricate biochemical pathways that converge on the FIR domain. The central role of the FIR domain is to facilitate protein-protein interactions that are critical for the activation of various cellular processes. For example, certain FIR Activators may bind directly to allosteric sites on the protein, inducing conformational changes that enhance the protein's ability to interact with its partners. This alteration in structure is not merely a passive change but actively promotes a more favorable interaction interface for protein complexes, which is crucial in processes such as signal transduction and cellular regulation.
The efficacy of FIR Activators is also attributed to their ability to influence the post-translational modifications of the target proteins. By affecting the phosphorylation state, these activators can either promote or stabilize the interaction of the FIR with other molecular motifs, thereby enhancing the protein's functional capacity. Some activators achieve this by inhibiting phosphatases that would ordinarily remove phosphate groups from the protein, thus maintaining the protein in a state that is conducive to interaction. Others may function by facilitating the addition of phosphate groups by kinases. The precise molecular interplay and the subsequent biochemical cascades that are triggered by these activators underscore their specificity and the fine-tuned control they exert on the FIR-bearing proteins, amplifying the integral interactions that are central to the protein's activity within the cell.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly elevates cAMP levels, which can lead to the activation of protein kinase A (PKA). PKA phosphorylation events can enhance the activity of FIR by modulating splicing events controlled by the PUF60 gene. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, thereby potentially activating calcium-dependent protein kinases which can influence the splicing machinery where FIR is a component. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a potent activator of protein kinase C (PKC), which can phosphorylate proteins involved in RNA processing, potentially affecting FIR function in alternative splicing. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several protein kinases and could lead to the reduced phosphorylation of competitive splicing factors, indirectly enhancing the splicing activity of FIR. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is known to cause DNA demethylation, which can alter the expression pattern of various splicing factors, thereby possibly facilitating an environment where FIR activity is upregulated. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs), and by changing the chromatin structure, it could affect the recruitment of splicing factors including FIR to pre-mRNA. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine induces autophagy and can modulate post-translational modifications of splicing factors. This could indirectly increase FIR activity by optimizing splicing factor composition. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride interferes with sodium channels, also affecting intracellular pH and calcium levels, which may indirectly enhance FIR activity by influencing the phosphorylation status of splicing factors. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, as an HDAC inhibitor, can alter chromatin structure and potentially enhance FIR activity by affecting gene expression and subsequent splicing events. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate cellular signaling pathways, potentially creating a cellular milieu that favors FIR-mediated splicing activity. | ||||||