Molecular structure of Amiloride, CAS Number: 2609-46-3
Amiloride (CAS 2609-46-3)
See product citations (7)
Alternate Names:
Amipramidin, Midamor
CAS Number:
2609-46-3
Molecular Weight:
229.63
Molecular Formula:
C6H8ClN7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Amiloride is a compound that is widely used in cellular and molecular biology research for its inhibitory effects on certain ion channels and transporters. In laboratory applications, scientists employ amiloride to study the function of epithelial sodium channels (ENaC) in various cell types, as it selectively blocks these channels and helps to elucidate their role in sodium balance and cellular signaling. Additionally, it is used to investigate the mechanisms of ion homeostasis and fluid balance within cells and tissues, providing insights into the fundamental processes governing cell physiology. Researchers may also use amiloride to explore its influence on intracellular pH and the regulation of hydrogen and potassium transport across cell membranes. Furthermore, amiloride is involved in studies pertaining to its effect on the Na+/H+ exchanger, which has implications for understanding the cellular mechanisms related to ion transport and volume regulation.
Amiloride (CAS 2609-46-3) References
- Amiloride and the Na(+)/H(+) exchanger protein: mechanism and significance of inhibition of the Na(+)/H(+) exchanger (review). | Harris, C. and Fliegel, L. 1999. Int J Mol Med. 3: 315-21. PMID: 10028059
- Mechanism of action of amiloride: a molecular prospective. | Kleyman, TR., et al. 1999. Semin Nephrol. 19: 524-32. PMID: 10598540
- Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty? | Matthews, H., et al. 2011. Int J Cancer. 129: 2051-61. PMID: 21544803
- Amiloride Analogs as ASIC1a Inhibitors. | Leng, TD., et al. 2016. CNS Neurosci Ther. 22: 468-76. PMID: 26890278
- The amiloride-blockable sodium channel of epithelial tissue. | Eaton, DC. and Hamilton, KL. 1988. Ion Channels. 1: 251-82. PMID: 2856493
- Amiloride Relaxes Rat Corpus Cavernosum Relaxation In Vitro and Increases Intracavernous Pressure In Vivo. | Campos, R., et al. 2019. J Sex Med. 16: 500-511. PMID: 30833152
- Allosteric modulation of G protein-coupled receptors by amiloride and its derivatives. Perspectives for drug discovery? | Massink, A., et al. 2020. Med Res Rev. 40: 683-708. PMID: 31495942
- Stability of extemporaneously compounded amiloride nasal spray. | Yellepeddi, V., et al. 2020. PLoS One. 15: e0232435. PMID: 32649677
- Amiloride: A review. | Sun, Q. and Sever, P. 2020. J Renin Angiotensin Aldosterone Syst. 21: 1470320320975893. PMID: 33234024
- Novel Amiloride Derivatives That Inhibit Bacterial Motility across Multiple Strains and Stator Types. | Islam, MI., et al. 2021. J Bacteriol. 203: e0036721. PMID: 34516280
- Amiloride in primary hyperaldosteronism. | Griffing, GT., et al. 1982. Clin Pharmacol Ther. 31: 56-61. PMID: 7053305
- Molecular properties of epithelial, amiloride-blockable Na+ channels. | Garty, H. 1994. FASEB J. 8: 522-8. PMID: 8181670
- Amiloride pharmacokinetics in rat. | Segre, G., et al. 1998. Eur J Drug Metab Pharmacokinet. 23: 218-22. PMID: 9725485
Inhibitor of:
αENaC, βENaC, 4930412D23Rik, 4930468A15Rik, 6030446N20Rik, 6330403A02Rik, 8D6, 9130011J15Rik, ACCN5, AI747448, Amphiphysin II, ANKRD61, Annexin IV, AQP3, AQP6, AROS-29, ARX, ASIC-β, ASIC1, ASIC2, ASIC4, ATP13A1, ATP1B3, BC014805, BC048943, BC049730, BOCT, C11orf20, C16orf33, C18orf30, C18orf58, C19orf29, C8orf79_6430573F11Rik, cadherin-28, CaT1, CHP2, CLC-1, CLCA3_Clac3, CLCC1, CLEC-18, CLRN2, CNG-1β, CNG-4, CNGA2, cyclin M1, cyclin M3, Doxl2, E030010A14Rik, EG240327, EG434008, EG435376, EG626682, EG626970, ESF1, ESPNL, FAM12, Glycophorin D, GlyR α2, Gm364, GPR89, granzyme H, GSDML, hnRNP A3, hole, IFITM5, Ik1, INTS3, KCC1, LDLRAD4, LEAP-2, Lipophilin A, LOC388564, LR8, Malcavernin, megalin, MFSD6, MFSD6L, MFSD9, mGBP8, MIP-T3, Mmgt2, Mover, MP19, MRS2L, Na+ CP type Iβ, Na+ CP type III, Na+ CP type Vα, Na+ CP type VIIα, NaS-1, NCKX1, NCKX2, NCKX3, NCKX4, NCX2, NHE-11, NHE-6, NHEDC1, NHEDC2, NIPA1, NIPA2, NKAIN1, Nova-2, nRNP, NSUN3, NSUN7, ODR4, Olfr1098, Olfr1101, Olfr347, Olfr38, Olfr437, Olfr449, Olfr463, Olfr464, Olfr466, Olfr467, Olfr495, Olfr508, Olfr522, Olfr561, Olfr564, Olfr566, Olfr569, Olfr639, Olfr64, Olfr649, Olfr65, Olfr665, Olfr739, Olfr771, Olfr776, Olfr777, Olfr780, Olfr782, Olfr784, Olfr805, Olfr823, Olfr834, Olfr835, Olfr836, Olfr851, Olfr853, Olfr854, Olfr860, Olfr869, Olfr923, Olfr924, Olfr926, Olfr93, Olfr965, Olfr967, Olfr968, Olfr969, Olfr97, Olr1517, Olr245, OR2D2, OR2J2, OR2T3, OR2T34, OR5V1, OR6C1, OR6C6, OR6C65, OR6C68, OR6C74, OR6C76, PAI-2, Pfpl, PIPES, Polr2j, PQLC3, Prestin, Protamine 2, Protein S, putrescine ABC transporter permease, R-type Ca++ CP α1E, R-type calcium channel α1E, RBM14, RNH1, SAP 62, SAT-1, SCARA5, SERINC1, SFRS14, Shigatoxin, SLC10A5, SLC10A6, SLC10A7, SLC22A23, SLC24A1, SLC26A11, SLC35F4, SLC38A11, SLC38A6, SLC41A1, SLC41A2, SLC41A3, SLC45A4, SLC46A3, SLC5A12, Sm, Sm D2, Sm F, SNAPC 190, SNAT6, sNHE, sodium channel type I, sodium channel type III, SPINK3, SPLUNC2, Stomatin, SUSD3, SVOP, T-type Ca++ CP α1G, T-type Ca++ CP α1I, T-type calcium channel α1G, T-type calcium channel α1H, T-type calcium channel α1I, T1R3, TIM-1, TMC2, TMC6, TMEM107, TMEM118, TMEM14A, TMEM150C, TMEM151B, TMEM154, TMEM156, TMEM161B, TMEM201, TMEM247, TMEM37, TMEM38B, TMEM63C, TMEM93, TMEM95, TRMP6, TSEN54, TTMB, Tuftelin, U2 snRNP A, uPA, uPAR, UST1R, V1RA1, V1RC, V1rc3132, V3R 8, Vmn1r15, Vmn1r17, Vmn1r184, Vmn1r196, Vmn1r30, Vmn1r34, Vmn1r61, Vmn1r86, Vmn1r88, Vmn2r106, Vmn2r24, Vmn2r68, Vmn2r99, VPS51, WDR43, ZCCHC8, and ZIP14.Activator of:
9G8, Ace3, AE3, ANG IV, AP-180, AP-2μ1, AP-2σ1, AQR, ASIC-β, ATP6F, ATP6V0E1, ATP6V0E2, band 3, Barttin, BC014805, BDV, BPI, C16orf33, CA VB, CASC3, CBP80, Clca6, CPSF1, CWC15, DDX33, EG435376, EG622976, EHBP1L1, FIR, GPATCH4, HAI-2, Histamine, IFN-α9, KLHL3, LOXL2, LSm4, MFSD5, MIPEP, Mumps, NEURL1B, NHP2, NKAIN3, Nurr1, OTOP2, OTTMUSG00000011275, PEPT2, PIEZO1, PN-1, PNPase, POLR2C, POLR2D, POM121L, PRPF40B, RBM12, RSRC2, SCRN3, SFRS11, Sialin, SLC12A8, Slc22a22, SLU7, Sm G, SMVT_Slc5a6, SNRPA, SNX17, Srrp, T2R48, TAF I p110_TAF I p95, TMC1, TMC4, TMEM150C, TREX-2, TRK-T3, TTYH1, U2AF26, V-ATPase α1, V-ATPase A2, V-ATPase D1, V-ATPase F, V-ATPase G2, V-ATPase H, and WNK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amiloride, 1 g | sc-337527 | 1 g | $290.00 |