FAM12A Activators
FAM12A activators engage in various biochemical pathways to enhance the functional activity of this specific protein. For instance, certain small molecules have the capacity to elevate the levels of intracellular messengers like cyclic AMP, which in turn activate key protein kinases within the cell. These kinases, once activated, can target a range of proteins, including FAM12A, resulting in its phosphorylation and consequent activation. This elevation of messenger molecules can be achieved through the inhibition of their breakdown or by directly stimulating their production. Furthermore, some activators function by increasing intracellular calcium concentrations, a signal that also activates calcium-dependent kinases. These kinases again have the potential to target and activate FAM12A by adding phosphate groups to specific amino acid residues, thereby modulating its activity.
Other compounds affect FAM12A activity through modulation of various signaling cascades that are involved in the phosphorylation state of proteins. Some agents, for example, can inhibit enzymes responsible for removing phosphate groups from proteins, leading to a net increase in protein phosphorylation, which may include FAM12A. Additionally, there are molecules that influence protein kinase signaling pathways by acting as agonists or inhibitors, thereby initiating a series of events that ultimately result in the activation of FAM12A.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C (PKC) that can phosphorylate target proteins including FAM12A, resulting in altered function and increased activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that stimulates the production of cAMP, subsequently activating PKA, which can lead to the phosphorylation and functional enhancement of FAM12A. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
A calcium ionophore which elevates intracellular calcium levels, potentially activating calcium-dependent protein kinases that could phosphorylate and increase the activity of FAM12A. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels and activation of PKA, possibly resulting in the phosphorylation and activation of FAM12A. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cell-permeable cAMP analog that directly activates PKA, leading to phosphorylation and potential activation of target proteins such as FAM12A. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol that can modulate various protein kinases and phosphatases potentially leading to the activation of downstream proteins, including FAM12A. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentration and may activate calcium-dependent proteins and kinases, which could phosphorylate and activate FAM12A. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
A protein synthesis inhibitor that can also activate stress-activated protein kinases, potentially leading to phosphorylation and activation of proteins such as FAM12A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can lead to altered signaling pathways, possibly resulting in compensatory activation or phosphorylation of FAM12A by other kinases. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins, which could indirectly increase the activity of FAM12A. | ||||||