elafin Activators
Elafin activators comprise a diverse group of compounds that can potentially enhance the expression or activity of Elafin through various molecular mechanisms. Resveratrol, for instance, acts as an activator by inhibiting the NF-κB signaling pathway, relieving the negative regulation imposed on Elafin. Similarly, Forskolin activates Elafin indirectly by influencing the cAMP-PKA pathway, modulating transcription factors that may regulate Elafin expression.Calcium ionophore A23187, on the other hand, can potentially activate Elafin by inducing intracellular calcium flux, triggering signaling pathways involved in Elafin regulation. SB203580, a p38 MAPK inhibitor, acts as an activator by relieving the inhibitory effects of p38 MAPK on Elafin expression. These compounds, along with others in the list, form a comprehensive toolkit for investigating the regulatory networks influencing Elafin expression.
Another group of Elafin activators includes compounds like Dimethyl Fumarate, Cisplatin, and Trichostatin A, each influencing distinct cellular processes. Dimethyl Fumarate activates the Nrf2-ARE pathway, leading to increased Elafin expression as a part of the antioxidant response. Cisplatin induces cellular stress, potentially activating protective mechanisms, including the upregulation of Elafin. Moreover, the epigenetic modulator Trichostatin A influences chromatin accessibility, potentially enhancing Elafin transcription. These diverse mechanisms highlight the multifaceted nature of Elafin regulation and provide researchers with valuable tools to explore the intricacies of Elafin's role in inflammation and tissue protection.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, can potentially activate Elafin by influencing the NF-κB signaling pathway. Resveratrol is known to inhibit NF-κB activation, leading to decreased pro-inflammatory gene expression. As Elafin is a downstream target of NF-κB, the suppression of this pathway by Resveratrol can indirectly upregulate Elafin expression, promoting its anti-inflammatory effects. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an adenylyl cyclase activator, may activate Elafin through the cAMP-PKA pathway. Forskolin elevates intracellular cAMP levels, leading to the activation of protein kinase A (PKA). Activated PKA can modulate transcription factors, possibly including those regulating Elafin expression. Consequently, Forskolin can act as an indirect activator of Elafin by influencing the cAMP-PKA signaling cascade. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, has the potential to activate Elafin by inducing intracellular calcium flux. Elevated intracellular calcium levels can activate various signaling pathways, potentially including those involved in the regulation of Elafin. A23187, by facilitating calcium influx, can modulate Elafin expression or activity, thereby acting as a potential indirect activator. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, may activate Elafin by blocking the inhibitory effects of p38 MAPK on Elafin expression. p38 MAPK is known to negatively regulate Elafin, and inhibition of this pathway by SB203580 could relieve the suppressive effects, leading to increased Elafin levels. Consequently, SB203580 can act as an indirect activator of Elafin by modulating the p38 MAPK signaling pathway. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $27.00 | 6 | |
Dimethyl Fumarate, an anti-inflammatory agent, may activate Elafin by influencing the Nrf2-ARE pathway. Dimethyl Fumarate activates Nrf2, a transcription factor involved in the antioxidant response. Activation of Nrf2 can lead to the upregulation of Elafin, as Elafin contains antioxidant response elements (AREs) in its promoter region. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin, a DNA-damaging agent, could activate Elafin by inducing cellular stress and DNA damage. Cellular stress responses, triggered by agents like Cisplatin, may lead to the activation of various protective mechanisms, including the upregulation of Elafin. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase (HDAC) inhibitor, may activate Elafin by modulating chromatin accessibility. HDAC inhibitors like Trichostatin A can alter the acetylation status of histones, leading to changes in gene expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), an AMP-activated protein kinase (AMPK) activator, may activate Elafin through the AMPK signaling pathway. AICAR activates AMPK, a cellular energy sensor, leading to downstream effects on various signaling pathways. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, a natural compound, may activate Elafin by affecting the STAT3 signaling pathway. Betulinic Acid has been reported to inhibit STAT3 activation. As Elafin expression is influenced by STAT3, the inhibition of this pathway by Betulinic Acid could lead to increased Elafin levels, making it a potential indirect activator of Elafin through modulation of the STAT3 signaling cascade. | ||||||
Difluoromethylornithine | 70052-12-9 | sc-204723 sc-204723A sc-204723B sc-204723C sc-204723D sc-204723E | 10 mg 25 mg 100 mg 250 mg 1 g 5 g | $58.00 $130.00 $158.00 $311.00 $964.00 $4726.00 | 2 | |
Difluoromethylornithine, an ornithine decarboxylase (ODC) inhibitor, may activate Elafin by influencing polyamine metabolism. ODC is involved in polyamine biosynthesis, and inhibition of ODC by Difluoromethylornithine can affect polyamine levels. | ||||||