Molecular structure of Dimethyl fumarate, CAS Number: 624-49-7
Dimethyl fumarate (CAS 624-49-7)
See product citations (6)
Alternate Names:
Fumaric acid; dimethyl ester; Fumaderm; Methyl fumarate; 2-Butenedioic acid (E)-, dimethyl ester
Application:
Dimethyl fumarate is an ester used for research purposes
CAS Number:
624-49-7
Purity:
≥98%
Molecular Weight:
144.13
Molecular Formula:
C6H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dimethyl fumarate (DMF) is derived from fumaric acid, a naturally occurring compound. Dimethyl fumarate holds significance within the fumaric acid cycle, which plays a pivotal role in energy production within the body. Moreover, Dimethyl fumarate assumes a vital role in the ubiquinone biosynthesis pathway, responsible for the generation of coenzyme Q10. While the precise mechanism of action for Dimethyl fumarate remains partially understood, it is postulated to exert its effects through antioxidation. By scavenging free radicals and diminishing oxidative stress, Dimethyl fumarate operates as an effective antioxidant.
Dimethyl fumarate (CAS 624-49-7) References
- Role of dimethyl fumarate in oxidative stress of multiple sclerosis: A review. | Suneetha, A. and Raja Rajeswari, K. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1019: 15-20. PMID: 26899449
- Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. | Kornberg, MD., et al. 2018. Science. 360: 449-453. PMID: 29599194
- Dimethyl fumarate downregulates the immune response through the HCA2/GPR109A pathway: Implications for the treatment of multiple sclerosis. | von Glehn, F., et al. 2018. Mult Scler Relat Disord. 23: 46-50. PMID: 29763776
- Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis. | Hosseini, A., et al. 2019. J Cell Physiol. 234: 9943-9955. PMID: 30536402
- Dimethyl fumarate, a two-edged drug: Current status and future directions. | Saidu, NEB., et al. 2019. Med Res Rev. 39: 1923-1952. PMID: 30756407
- Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice. | Casili, G., et al. 2020. J Neuroinflammation. 17: 59. PMID: 32066464
- Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature. | Dello Russo, C., et al. 2021. Pharmacol Ther. 219: 107710. PMID: 33091427
- Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2. | Yang, Y., et al. 2021. Clin Transl Med. 11: e382. PMID: 33931960
- Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway. | Yan, N., et al. 2021. Int Immunopharmacol. 98: 107844. PMID: 34153667
- Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia. | Diebold, M., et al. 2022. Ann Neurol. 91: 676-681. PMID: 35170072
- Dimethyl fumarate ameliorates autoimmune hepatitis in mice by blocking NLRP3 inflammasome activation. | Shi, FL., et al. 2022. Int Immunopharmacol. 108: 108867. PMID: 35605433
- Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis. | Qi, D., et al. 2023. Cell Cycle. 22: 818-828. PMID: 36482709
- The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies. | Manai, F., et al. 2022. Cells. 11: PMID: 36552824
Inhibitor of:
14-3-3 σ, 4930558K02Rik, AFX1, AKR7A3, ALKBH3, AROS-29, BACH1, BTN3A1, COL4A1, DHRS13, DRP1, fumarate hydratase, GLYATL1, Glyoxalase I, Gm239, IgG λ light chain, JMJD2B, Keap1, KIAA0776, L3HYPDH, Mel13, MGST1, Mrf-2, MsrA, NALP1, NGAL, PACSIN1, Prominin 2, psmd1 inhibitors, Radixin, resistin, Ros, SGS3, T-cell receptor Vδ 1, THP, TPPP3, and WC1.Activator of:
3830417A13Rik, ALG14, ANKRD45, C1orf144, C20orf195, C330021F23Rik, CD6, CoREST, COX7a1, DDX16, DDX30, DDX31, DDX34, DDX37, DDX52, EG433016, EG433182, elafin, Frataxin, Fv1, G6pd2, GGCT, GSTO2, GSTT4, HHLA2, HLA-E, IDH1, IgM, IMPDH1, IRP-1, LOC100040158, LOC100040870, LOC100041115, LOC100041339, M83, Macrophage Marker, MafG, MafK, MAL, Mel13, MIP-1α, MRP-S17, NF-E2, NF-E2 p18, Nrf2, Nur77, OKL38, polycyclic aromatic hydrocarbons, PR3, PRX II, RFX5, Sptrx-1, Stat4, stefin A1, stefin A2, TAFA2, Trx-2, TXNDC10, and ZNF281.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dimethyl fumarate, 25 g | sc-239774 | 25 g | $27.00 |