Date published: 2025-12-13

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elafin Inhibitors

Elafin inhibitors constitute a diverse group of compounds designed to modulate the activity of Elafin, an endogenous protease inhibitor known for its roles in inflammation and tissue protection. Among these inhibitors, Lactacystin, MG-132, Epoxomicin, Bortezomib, Iodoacetamide, Z-FA-FMK, Marimastat, TAPI-2, ALLM, Calpeptin, E-64d, and Dexamethasone have been identified as potential agents to influence Elafin activity. These inhibitors act through various mechanisms, providing valuable insights into the regulation of Elafin-mediated cellular processes. Proteasome inhibitors such as Lactacystin, MG-132, Epoxomicin, and Bortezomib directly inhibit Elafin by halting its degradation through the ubiquitin-proteasome system. By stabilizing Elafin levels, these inhibitors increase its accumulation and potentially modulate its inhibitory function. Cysteine protease inhibitors, including Iodoacetamide and E-64d, directly target cysteine residues involved in Elafin's inhibitory function, providing a direct approach to modulate Elafin activity. Inhibitors like Z-FA-FMK, Marimastat, TAPI-2, ALLM, and Calpeptin indirectly modulate Elafin by targeting specific proteases or enzymes involved in its activation or cleavage. Z-FA-FMK, a caspase inhibitor, stops caspase-mediated cleavage or activation that may regulate Elafin function. MMP inhibitor Marimastat and TACE inhibitor TAPI-2 interfere with MMP- and TACE-mediated processes, respectively, influencing Elafin downstream events. Calpain inhibitors ALLM and Calpeptin stop calpain-mediated cleavage or activation that may regulate Elafin function. Additionally, the glucocorticoid receptor agonist Dexamethasone indirectly influences Elafin by modulating the expression or activity of upstream regulators. Dexamethasone impacts relevant signaling pathways, potentially altering Elafin levels or function. This diverse array of Elafin inhibitors offers a molecular toolkit to investigate the consequences of altered Elafin function, providing valuable insights into the complex regulatory networks involved in inflammation and tissue protection mediated by Elafin.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

Lactacystin, a proteasome inhibitor, directly inhibits Elafin by preventing its degradation through the ubiquitin-proteasome system. By inhibiting proteasomal activity, Lactacystin increases Elafin levels, leading to its accumulation and potential modulation of its inhibitory function.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

MG-132, a proteasome inhibitor, directly inhibits Elafin by preventing its degradation through the ubiquitin-proteasome system. By inhibiting proteasomal activity, MG-132 increases Elafin levels, leading to its accumulation and potential modulation of its inhibitory function.

Epoxomicin

134381-21-8sc-201298C
sc-201298
sc-201298A
sc-201298B
50 µg
100 µg
250 µg
500 µg
$134.00
$215.00
$440.00
$496.00
19
(2)

Epoxomicin, a proteasome inhibitor, directly inhibits Elafin by preventing its degradation through the ubiquitin-proteasome system. By inhibiting proteasomal activity, Epoxomicin increases Elafin levels, leading to its accumulation and potential modulation of its inhibitory function.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib, a proteasome inhibitor, directly inhibits Elafin by preventing its degradation through the ubiquitin-proteasome system. By inhibiting proteasomal activity, Bortezomib increases Elafin levels, leading to its accumulation and potential modulation of its inhibitory function.

α-Iodoacetamide

144-48-9sc-203320
25 g
$250.00
1
(1)

Iodoacetamide, a cysteine protease inhibitor, directly inhibits Elafin by targeting cysteine residues involved in its inhibitory function. By blocking cysteine protease activity, Iodoacetamide modulates the function of Elafin, potentially affecting its inhibitory role in relevant pathways.

Z-FA-FMK

197855-65-5sc-201303
sc-201303A
1 mg
5 mg
$125.00
$365.00
19
(1)

Z-FA-FMK, a caspase inhibitor, indirectly inhibits Elafin by preventing caspase-mediated cleavage or activation that may regulate Elafin function. By inhibiting caspase activity, Z-FA-FMK can influence the downstream events related to Elafin, potentially modulating its inhibitory function.

Marimastat

154039-60-8sc-202223
sc-202223A
sc-202223B
sc-202223C
sc-202223E
5 mg
10 mg
25 mg
50 mg
400 mg
$165.00
$214.00
$396.00
$617.00
$4804.00
19
(1)

Marimastat, a matrix metalloproteinase (MMP) inhibitor, indirectly inhibits Elafin by preventing MMP-mediated cleavage or activation that may regulate Elafin function. By inhibiting MMP activity, Marimastat can influence the downstream events related to Elafin, potentially modulating its inhibitory function.

TAPI-2

187034-31-7sc-205851
sc-205851A
1 mg
5 mg
$280.00
$999.00
15
(1)

TAPI-2, a TNF-α converting enzyme (TACE) inhibitor, indirectly inhibits Elafin by preventing TACE-mediated cleavage or activation that may regulate Elafin function. By inhibiting TACE activity, TAPI-2 can influence the downstream events related to Elafin, potentially modulating its inhibitory function.

ALLM (Calpain Inhibitor)

136632-32-1sc-201268
sc-201268A
5 mg
25 mg
$140.00
$380.00
23
(1)

ALLM, a calpain inhibitor, indirectly inhibits Elafin by preventing calpain-mediated cleavage or activation that may regulate Elafin function. By inhibiting calpain activity, ALLM can influence the downstream events related to Elafin, potentially modulating its inhibitory function.

Calpeptin

117591-20-5sc-202516
sc-202516A
10 mg
50 mg
$119.00
$447.00
28
(1)

Calpeptin, a calpain inhibitor, indirectly inhibits Elafin by preventing calpain-mediated cleavage or activation that may regulate Elafin function. By inhibiting calpain activity, Calpeptin can influence the downstream events related to Elafin, potentially modulating its inhibitory function.